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Gastro-oesophageal reflux symptoms are related to the presence and severity of obstructive sleep apnoea. The percent of time when hearing protection was used during noise levels above 85 dBA nearly doubled post-training, and the change was statistically significant. The duration of response in all three species approximated the minimum duration of response necessary for reinforcement. In this review, we briefly discuss the role of mitochondrial DNA mutations, mitochondrial dysfunction, and ROS generation in the development of heart disease and recent developments in mitochondria-targeted antioxidants for the treatment of heart disease.

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The results showed that age, histologic type of carcinoma, myometrial invasion, tumor grade, peritoneal cytology, tumor size, ER and PR status are significant predictors for recurrence and prognosis of FIGO I, II stage endometrial carcinoma. It was demonstrated that the plasma PAF level was markedly higher and the serum PAFAH activity markedly lower in the asthmatic patients, both in remission and at the time of asthmatic attack, than in the healthy volunteers. Distribution characteristics at each state, temporal and spatial trends, multivariate analyses, and the causes were analyzed to assess the pollution level, which aimed to offer a database for drafting the national baseline values of SEM in seawater and sediment in future.

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Plasma samples were taken before ECT and 1, 60 and 120 min thereafter. The model worked well for the compounds tested with a root mean square error of prediction of 5.50s across all compounds, phases, and temperature ranges studied. Measuring quality in diabetes care: an expert-based statistical approach.

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Analysis of adverse events associated with endoscopic papillary large-balloon dilation. This region encompasses a potential metal-binding site containing the motif DXSXS, which is required for ligand interaction in the homologous I-type domains of integrins CR3 and LFA-1.

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Calcium chelators also attenuated Hcy-induced reactive oxygen species (ROS) production in macrophages, indicating that Hcy-induced COX-2 expression might be mediated through ROS generated by calcium-dependent signaling pathways. In addition, our investigation of actin polymerization indicates that loss of cell-surface adhesion changes actin polymerization at cell-cell contacts.

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The executive secretaries were encouraged to seek input from other board staff and board members in formulating a response. Importantly the ambiguity in estimation of theta is not carried through to the lod score as this depends only on the maximum value of the likelihood and not on the particular value of theta at which it occurs. We investigated the roles of eosinophil infiltration and activation induced by the eosinophil-selective chemokine eotaxin, and of the expression of eosinophil alpha4 and beta2 integrins in causing bronchial hyperresponsiveness (BHR) in interleukin (IL)-5 CBA/Ca transgenic mice. The role of cognitive-behavioural therapy in the management of pain in patients with sickle cell disease. Optogenetic pharmacology for control of native neuronal signaling proteins.

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SKF 38393 failed to exert any significant effect on the LMA of the mouse. The size dependence of the second virial coefficient points to an interparticle interaction that is proportional to the QD surface area. Orally administered haloperidol, chlorpromazine, thioridazine, clozapine, and diazepam blocked a conditioned avoidance response in male beagle dogs. To report the final height (FH) of 76 patients with Turner syndrome (TS).

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Based on functional analysis of DCL proteins identified in Arabidopsis thaliana, four types of DCLs were distinguished (DCL1-4). Viral, bacterial, and fungal infections occurring during this period were evaluated.

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The cytokine tumor necrosis factor (TNF) plays a central role in the pathogenesis of rheumatoid arthritis (RA), but its disease-specific effector mechanisms have not been fully elucidated. Acute appendicitis is very unlikely when both the leucocyte count and CRP value are normal. We suggest that future initiatives aimed at identifying priority conservation questions and horizon scanning topics should allow simultaneous identification of both current and future priority issues, as presented here for the first time. A life history view of mutualistic viral symbioses: quantity or quality for cooperation? In both the postoperative cleft palate patients and controls, the sensation in the anterior region of the hard palate was more numb than that in the anterior region of the soft palate or the premolar alveolar region.

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Personal and relationship challenges of adults with type 1 diabetes: a qualitative focus group study. Randomized double masked trial of Zhi Byed 11, a Tibetan traditional medicine, versus misoprostol to prevent postpartum hemorrhage in Lhasa, Tibet.

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Increased permeability of the intestinal mucosa to small molecules and ions has previously been proposed as a mechanism causing the profuse diarrhoea characteristic of Asiatic cholera. Perineal and rectal damage following nonpenetrating abdominal trauma. PCR conditions were optimised and products were verified by restriction endonuclease digestion and agarose gel electrophoresis. Participants also recorded information on symptoms, peak expiratory flows (PEF) and medication use. The typical dual-activation mode is prohibited by this catalyst encapsulation, leading to typical behavior as a result of mononuclear activation.

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Facial painful diseases impact the quality of life of adults and should be diagnosed and treated. Blood flow and O2 uptake in dog hindlimb with anemia, norepinephrine, and propranolol. Dual catalysis: new approaches for the polymerization of lactones and polar olefins.

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During high ratio DCR, resuscitation with higher volumes of crystalloids was associated with an overall decreased survival, whereas low volumes of colloid use were associated with increased survival. Methyl arachidonyl fluorophosphonate (MAFP), an inhibitor of phospholipase A2 (PLA2), has been widely used to assess the roles of PLA2 in various cell functions. High dose and short-term streptokinase infusion in patients with pulmonary embolism: prospective with seven-year follow-up trial.

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A microscopic fluorescence imaging system is used to detect optically active centers located inside a transparent dielectric crystal. Cough, wheeze, runny nose, and doctor-diagnosed asthma were significantly more often reported for children living within 100 m from the freeway. Induction chemotherapy followed by concurrent cetuximab and RT to 68 Gy is clearly feasible with promising survival. Cavities of varying depths were drilled in the middle or apical thirds of each tooth root according to 3 setups: slight (0.15, 0.20, and 0.30 mm), moderate (0.60 and 1.00 mm), and severe (1.50, 2.00, and 3.00 mm) resorption. Therefore the joint effect of PA and salt on nuclei at certain conditions may lead to formation of artefact structures.

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However, the staged approach did not improve time to first AT/AF recurrence. The introduction of cardiotocography failed to reduce serious perinatal morbidity or mortality as compared with intermittent auscultation, but did increase the number of obstetrical interventions.

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PA interacts with mTOR in a manner that is competitive with rapamycin, and as a consequence, elevated PLD activity confers rapamycin resistance - a point that has been largely overlooked in clinical trials involving rapamycin-based strategies. The purpose of this study was to examine the effects of ONOO(-) on contractile function at the level of the single cardiac myocyte and whether this includes the action of MMPs.

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On the basis of the DFT calculation and kMC simulation results, a new mechanism is proposed. For reversals, the Frz chemosensory system induces the relocation of MglA/GTP to the lagging pole causing an inversion of the leading/lagging polarity axis. As a result, Nrf2 enhances the expression of glutathione and antioxidants such as superoxide dismutase and glutathione S-transferase, and subsequently scavenging free radicals.

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Participants underwent a standardized MDT assessment and were classified into the following pain-pattern subgroups: DP with CEN, DP without CEN, or no DP. Drug-incorporated NPs for local delivery might optimize the efficacy and minimize the side effects of drugs. Extramedullary plasmacytoma of the colon: a rare cause of intussusception.

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Diseases transmitted from animals to humans, referred to as zoonoses, pose risks for persons occupationally exposed to animals. Aspirin in the lyophilized inclusion complex exhibited the most significant degree of degradation during the 6-months storage, while aspirin alone in the pMDI demonstrated a moderate degree of degradation. sinensis first appeared in MC contacts but gradually moved towards the cell wall regions facing the intercellular spaces, while in A.

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In the follicular phase of the cycle, progesterone levels were consistently less than 2 ng/ml. Licorice infusion: Chemical profile and effects on the activation and the cell cycle progression of human lymphocytes. The uptake of 36C1 into astrocytes in tissue culture by a potassium-dependent, saturable process: implications for epilepsy and cortical edema. A control system is responsible for deciding which method should be used in each instant.

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Characterizing the Acute Phase Response in Healthy Patients Following Total Joint Arthroplasty: Predictable and Consistent. Knowledge of instrumental complications is vital both in interpreting experimental observations and in achieving true results. Here we develop CPTL, a Collective Prediction based on Transduction Learning, to systematically prioritize miRNAs related to disease. Studies of myocardial aging are complex and the mechanisms involved in the deterioration of ventricular performance and decreased functional reserve of the old heart remain to be properly defined. Transplant vasculopathy (TV) remains the most common cause of long-term mortality in cardiac transplant recipients.

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We describe the use of clusterin-specific antisense oligonucleotides and antibodies to sensitize breast carcinoma cells to anticancer drugs routinely used in breast cancer therapy. MS did not counteract TS-induced effects because no significant difference was found between TS/MS and TS animals. The studies differed in type of intervention, type of outcome, and follow-up time. The characteristic hypopigmented streaks along the Blaschko lines were associated with hypertrichosis of the genitals and shins, as well as musculoskeletal and dental anomalies. Results of 155 cases after endoscopic laser-assisted diverticulotomy and the transcervical approach were retrospectively compared.

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Heart rate variability in premature neonates pre-and postmethylxanthine administration. Effect of prone and supine positions on functional residual capacity, oxygenation, and respiratory mechanics in ventilated infants and children. To conduct a cross-cultural adaptation of the Core Outcome Measures Index (COMI) into French according to established guidelines. Monitoring of L-Arginine and Endogenous Dimethylarginines in Survivor Septic Patients - A Pilot Study. Edematous dark-brown colored lesions of mucosal surface were discontinuously observed from terminal ileum to sigmoid colon with bloody ascites.

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Both receptor and ligand were found associated with the membrane of clathrin-coated vesicles close to the cell surface. Analysis of bT-NPT relations by age groups revealed a significant association between bT and duration NPT in men ages 55 to 64 years, but no statistical relations in younger and older age groups. Circulatory and symptomatic effects of physical training in patients with coronary-artery disease and angina pectoris.

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This model can account not only for the results, which indicate the presence and a substantial degree of generalizability of especial skill to nearby distances, but also for results of the original study on especial skill where it was proposed that specificity in practice leads to the emergence of the especial skill. We used a Bayesian hierarchical model combined with country-specific time trends to yield estimates of these indicators and uncertainty assessments. To determine the correlation of patient-reported pain with physical function and health-related quality of life (HRQoL) after spine surgery and to determine the responsiveness of pain, physical function, and HRQoL after spine surgery. A careful review of previous research is presented and it is highlighted that uniquely for downy mildews, Poakatesthia may form an intracellular mycelium, growing through several host cells. Records of all patients transferred from a general medical floor (GMF) to the ICU were audited.

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In subsequent analyses, random change point models were used to examine the relation of the pathologic indices with the onset of terminal decline and rates of preterminal and terminal decline (ie, nonlinear decline). Genome-wide association studies provide information implicating 5,10-methenyltetrahydrofolate synthetase (MTHFS) as a candidate gene for renal disease. Vascular pathology in SHRSP proceeds in definite stages, whereas an age-dependent accumulation of erythrocytes in capillaries and arterioles represents the homogeneous initial step of the disease. It attenuates the adaptive immune response by sequestering T cells within secondary lymphoid organs via its action as functional antagonist of sphingosine-1-phasphate.

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Interactions between the autonomic nervous system and the cardiovascular effects of ouabain in guinea-pigs. Ljung-Box Q statistics was used for model diagnosis, and R squared or stationary R squared was taken as goodness of fit measure. A beneficial effect on pulmonary function was rarely measured or observed.

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In part because of this discrepant treatment across the DSM-IV manual, catatonia is frequently not recognized by clinicians. Abnormal thallium stress test and normal coronary angiograms: catheterization and clinical characteristics. Viruses also use RNA splicing to maximize their coding potential and economize on genetic space, and use clever strategies to manipulate the splicing machinery to their advantage. Our findings indicate that the short retromandibular approach is an easy and safe technique for displaced subcondylar fractures.

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The three integrated phases of left atrial macrophysiology and their interactions. To analyze the reason and strategy for failure of posterior pedicle screw short-segment internal fixation on thoracolumbar fractures. These data support an important function of sprouty-related Ena/vasodilator-stimulated phosphoprotein homology 1-domain-containing protein-2 in controlling influenza virus-induced pneumonia and viral replication.

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Using a one-channel or two channel method, all tumors were completely resected without serious complications and the diagnosis was histologically confirmed. However, viral RNP isolated from infected cells shows only a small amount of kinase activity.

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To investigate the relationship between and underlying mechanistic pathway of clusterin (CLU) and chemo-resistance ofhepatocellular carcinoma (HCC) cells. These data suggest that the use of the saphenous vein to identify potent vasoconstrictors will also reveal agents capable of contracting human coronary arteries, a liability for using this approach to evaluate promising antimigraine therapies.

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FGF23: mediator of poor prognosis in a sizeable subgroup of patients with castration-resistant prostate cancer presenting with severe hypophosphatemia? Participants for this analysis were drawn from a cohort of 2408 employees and retirees of a university in San Diego who were examined for venous disease using duplex ultrasonography. We report here that PNS disease in HIV-infected individuals is associated with intrathecal synthesis of an antibody directed against sulfatide, a major component of myelin. Presynaptic assembly requires the packaging of requisite proteins into vesicular cargoes in the cell soma, their long-distance microtubule-dependent transport down the axon, and, finally, their reconstitution into functional complexes at prespecified sites. Ribosomal protein uS19 mutants reveal its role in coordinating ribosome structure and function.

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Reducing the in-vitro electromagnetic field effect of cellular phones on human DNA and the intensity of their emitted radiation. However, induced anxiety as defined by less stringent criteria (i.e., physiological or verbal indices alone), decreased discriminability, but not response bias, and the decrease was less than in patients who were defined as anxious by the more comprehensive criteria. Patient-specific risk can be defined by a combination of clinical evaluation and noninvasive testing, much of which is aimed at detecting the presence and staging the severity and stability of CAD. Serum levels of IgM and IgG4 were extremely low at 3.0mg/dl and less than 2.0mg/dl, respectively. SOX2 is a core component of the transcriptional network responsible for maintaining embryonal carcinoma cells (ECCs) in a pluripotent, undifferentiated state of self-renewal.