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Double-blind, placebo-controlled study of metrifonate, an acetylcholinesterase inhibitor, for Alzheimer disease. Characterization of proteins utilized in the desulfurization of petroleum products by matrix-assisted laser desorption ionization time-of-flight mass spectrometry. These results provide evidence that Pb exposure during development alters axonal structure and function within brainstem auditory nuclei.

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All patients had CF and ranged in age from 10 months to 20 years. Twenty minutes before entering the operating room, slight urticaria was caused by drop infusion of cefotiam.

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Eighteen consecutive children had neck US performed using an ATL 5000 unit with a 12.5 MHz liner probe. Implantation of oestradiol into the anterior hypothalamus (via guide cannulae) also activates proceptivity.

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In one patient, left ventricle invasion was seen and it was totally excised. The purpose of this retrospective study was to evaluate the role of (18)F-FDG PET or PET/CT in the prediction of patient outcome in children and young adults affected by rhabdomyosarcoma. X irradiation of spleen cells before Con A treatment also abrogated generation of suppressor cell activity. The DIF analyses were performed using a simple Rasch model procedure.

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Three separate clones not previously exposed to chemotherapeutic drugs exhibit resistance to doxorubicin, vincristine, and colchicine that is similar to MDR transfectants not previously exposed to chemotherapeutic drugs. However, modification of energy source of the PB1 medium by reducing Na-pyruvate concentration and adding lactate salts gave also high maturation rate. Age of onset and number of polypectomies per person-year of post-surgical follow-up were compared in two FAP families with very close mutation sites in the APC gene, in order to ascertain mutation-specific variation of expressivity. The aim of this study was to define the clinical indications and demographic characteristics of patients under-going open reduction for developmental dysplasia of the hip (DDH), and determine the proportion due to preventable failures of contemporary clinical screening and early management. In vitro desaturation of 1-14C linoleic acid in Novikoff hepatoma.

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virB4, virB8 and virB9 are duplicated, yet only one copy of each has the conserved features of similar genes in other T4SSs. We studied the role of the RAS in the cerebral and ocular circulation in healthy subjects.

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Peripheral vascular disease, in which patients have no palpable distal pulses, should be considered a possible contraindication to the use of a tourniquet during TKA. IGF-I-stimulated phosphorylation of AKT on serine(473) but not threonine(308) was decreased in omental cells, and activation of downstream targets, including S6Kinase, glycogen synthase kinase-3, and Forkhead box O1 was also impaired. We have adopted this system as a model for single-cell level analyses of topographic map formation and examined when and how the lateral line topographic map is established.

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It is interesting to identify a minimal set of proteins whose removal would lead to a massive disruption of protein complexes and, to understand the biological properties of these proteins. To examine the mechanism involved in this decrease in RNA, naloxone (7.5 mumol/kg), an opioidergic receptor antagonist, was intravenously injected 1 min after the end of hemorrhage.

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Lastly, the limited number of long-term randomized, head-to-head studies involving direct comparison with TV-ICDs poses a challenge in the implementation of the S-ICD. However, any of the combination OC products that contain these progestins may be prescribed for women intolerant of older agents or to first-time users of OCs. Compared with the once-daily dosage regimen, the administration of endostatin by an osmotic pump achieved a similar arthritis-inhibiting effect at one-tenth of the dose. These results are in agreement with those reported in the literature, and they characterize the adaptation of biological tissue to external stimuli. We particularly observed the clinical presentation and long-term clinical, oncological and radiological evolution.

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The functional roles of NFKB1 and RELA in GC were demonstrated by MTT proliferation assay, monolayer colony formation, cell invasion and migration, cell cycle analysis and in vivo study through siRNA mediated knockdown. We developed the hyper extension-internal rotation (HERI) test to assess the IGHL and inferior capsule without causing apprehension or inducing a risk of gleno-humeral dislocation. Usability of the Massachusetts Prescription Drug Monitoring Program in the Emergency Department: A Mixed-methods Study. The purpose of this paper is to adapt and use the NDI-35 questionnaire in Greek nursing practice. Studies on protein and amino acid metabolism of gastric cancer patients.

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ECG recordings were analysed within a randomized, controlled clinical trial evaluating the efficacy and tolerability of maintenance treatment with LAAM compared with racemic methadone. In addition to being crucial for epidermal appendage initiation, they control the interfollicular spacing pattern and contribute to the spatial orientation and largely parallel alignment of hair follicles. To elucidate the mechanism of activation of procaspase-9 by Apaf-1, we designed an in vitro Apaf-1-procaspase-9 activation system using recombinant components. Female SCID mice, devoid of functional T lymphocytes, and wild-type (WT) C57BL/6 were treated with a high-fat high-simple carbohydrate (HFHSC) diet for 12 months. This avian influenza A H7N9 virus is a triple reassortant of viruses that are avian-origin only and it is low pathogenic in poultry.

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Variables can therefore be adjusted with instantaneous outcomes visually displayed. These findings suggest that an elevated superoxide/hydrogen peroxide ratio activates NFAT in pulmonary arteries, which induces vascular remodeling and increases vascular reactivity leading to PH. Irradiation with a SOL 3 apparatus (solar simulating irradiation) revealed hemolysis in the presence of five oral hypoglycemic agents and in the presence of 19 out of the 25 tested diuretics. The MWBM results showed a very good agreement with field data whilst it was observed that peak precipitation rates followed a parallel trend with peak leachate generation rates. Disruption of CD44-hyaluronan interaction by soluble recombinant CD44 has been shown to inhibit tumor formation by lymphoma and melanoma cells transfected with CD44.

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Adducts were separated by HPLC on a 3-mm Nova-Pak C18 reversed-phase column using isocratic elution with a solvent of acetonitrile-0.15 M phosphoric acid (5:95) buffered at pH 2.5. Accordingly, various surgical and medical methods aim to increase flap survival.

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From these data, the affinity of adenosine for the high- and low-affinity states of the human adenosine A1 receptor (7 x 10(7) and 1.3 x 10(5) M-1, respectively) was calculated. The MAbs to ICAM-1 and LFA-1 were injected for 3 days after transplantation in some recipients, and others were treated with FK506. Furthermore, we investigated lymphocyte and monocyte expression of LFA-1 (CD11a/CD18) and VLA-4 (CD49d/CD29) ligands for ICAM-1 and VCAM-1, respectively.

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Preparation of submicrometer monodispersed magnetic silica particles using a novel water in oil microemulsion: properties and application for enzyme immobilization. We describe a surgical case of this syndrome that was accompanied by neurological signs associated with cervical syringomyelia. Previously we have reported that Eutypella spp - CrP14 isolated from stem cutting of this plant had shown significant antiproliferative activity when tested in vitro against HeLa cell line.

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To assess oxidative damage to DNA during lung cancer (LC) treatments. The damaged area in older preparations was restricted to the crush site with normal astrocytes, oligodendrocytes and neurons immediately adjacent to the lesion. Alternatively these interactions can be thought of as a contribution-dependent change in regional responses to an experimental or psychological factor. Randomized controlled trials comparing methotrexate with placebo or an active comparator in patients with active ulcerative colitis were considered for inclusion.

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As a consequence, the embryonic cortex of neonatal rabbit kidneys was fixed in solutions containing glutaraldehyde in combination with cupromeronic blue, ruthenium red or tannic acid. Fourth, the results from analysis of different statistical models were compared and discussed.

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Albendazole : a comparison of relay embryotoxicity with embryotoxicity of individual metabolites. To describe a clinical staging method linked to stepwise treatment indications for ketamine-associated urinary dysfunction (KAUD) based on review of our experience in management of KAUD patients and analysis of their clinical features. This prospective study was performed in an outpatient clinic of radiation oncology with a sample of 54 consecutive patients. Substances which appear to be S-ethylglutathione and S-ethylglutathione sulphoxide have been detected in the bile of rats dosed with urethane or N-hydroxyurethane. Specifically, we investigate the reaction of estrous female red deer (Cervus elaphus) to playbacks of red deer vs.

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Whole chromosomal painting covering the whole chromosome facilitates the rapid analysis of chromosome structural abnormalities, and centromere staining using alphoid DNA probes allows rapid analysis of chromosome numerical aberrations. We sought to quantitatively determine the inter-observer variability of expert radiotherapy target-volume delineation for thymic cancers, as part of a larger effort to develop an expert-consensus contouring atlas. Our current understanding of the dermal-epidermal junction forms a new model encapsulating the nature both of the hemidesmosomal attachment structures and of the interhemidesmosomal attachments that are mediated by differential cell type specific expression of proteins of the cutaneous adhesion zone.

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Myocardial biopsies were stained immunohistochemically to investigate fibroblast phenotype and examine evidence of active remodeling in the heart. Strain specific cell-mediated response to polyoma-transformed fibroblasts in mice.

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Hypoxia is a critical secondary injury mechanism in traumatic brain injury (TBI), and early intervention to alleviate post-TBI hypoxia may be beneficial. The Elicitation Interview is a method for gathering detailed and precise accounts of human experience. Clinical experience of medullary thyroid carcinoma in Chang Gung Memorial Hospital. This study confirms the detrimental effects of meconium aspiration and the impairment of lung function following saline-BAL. This study evaluated the osteointegration of threaded cylindrical uncoated endosseous implants in combination with either bovine bone morphogenetic protein (bBMP) (group 1) or bovine serum albumin (BSA) (group 2) in edentulous dogs.

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With three consecutive tetratricopeptide repeat (TPR) motifs at its C-terminus essential for neuronal migration, and a p23 domain at its N-terminus, DYX1C1 was the first gene proposed to have a role in developmental dyslexia. In the light of contradictory data on efficacy and safety of NSAID in cardiovascular patients selection of most appropriate NSAID (basing on profile of efficacy and safety) in patients receiving continuous therapy with low dose aspirin appears to be a problem. Results showed that DNA copy number abundances of EGFR, ERBB2, ERBB3, and ERBB4 had associations with overall survival in lung adenocarcinoma with EGFR-activating mutations. CYP1A1 genetic polymorphism and polycyclic aromatic hydrocarbons on pulmonary function in the elderly: haplotype-based approach for gene-environment interaction.

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A CE method for investigating the chemico-physical characteristics of the active components of low molecular weight in Gastrodia elata Bl. Nurses can be instrumental in overcoming the barriers that prevent some clinicians from adopting these useful information systems.

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To describe the clinical and epidemiological factors of influenza A (H1N1)pdm09-infected patients who were pregnant or in the puerperal period during a recent influenza outbreak in Rajasthan, India. Identification of Aphis gossypii Glover (Hemiptera: Aphididae) Biotypes from Different Host Plants in North China. An unusual cause of gastric retention without outlet obstruction. Here, the common themes of glycosylation are conceptualised for the major classes of prokaryotic (i.e.

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Histopathological, Immunocytochemical and Ultrastructural examination of the right basal ganglionic mass showed features characteristic of angioleiomyoma. Gene expression and larval evolution: changing roles of distal-less and orthodenticle in echinoderm larvae. Multirater and multimethod data from a national sample of 516 nondivorced and remarried families from the Nonshared Environment and Adolescent Development (NEAD) project were examined using a combination of cluster, factor, and regression analyses. These results demonstrate that a learning health system can be developed and implemented in a cost-effective manner, and can integrate clinical care and research to systematically drive simultaneous clinical quality improvement and reduced healthcare costs.

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The cytopathogenic biotype of the pestivirus, bovine viral diarrhea virus, is frequently a product of nonhomologous recombination in the region of the genome encoding the viral NS2-NS3 proteins. E.carotovora mutants defective in synthesis of the pectinase, cellulase and protease exoenzymes were isolated and classified into two groups.

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Clinical, radiological and histological findings as well as possible etiologies are discussed. Probiotic lactobacilli can positively impact on the health status of targeted (diseased) populations but efficacy depends strongly on the strain employed and the molecular basis for this phenomenon is poorly understood. Magnetic field gradient system for nuclear magnetic resonance microimaging. Overall, the magnitude of the induction was correlated inversely with the rates of hydrolysis, but positively with the activation of the pregnane X receptor (PXR).

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Because the medical gain is unclear, the cost per life gained can not be estimated. First-generation mouse tumour models, which used transgenic mice or conventional knockouts, are now being superseded by models that are based on conditional knockouts and mice that carry regulatable oncogenes.

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However, the great limitation of studying adult animals is that the animal must be sacrificed and its tissues/organs extracted, which prevents the study of the infectious processes in the whole living animal. Study models and lateral cephalograms were taken before and after the distalizing movement to record significant dental and skeletal changes (Wilcoxon test). Gastric cancer represents a major health burden worldwide and is often diagnosed at an advanced stage.

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For example, users who score high on sociability and reciprocity but low on utility may learn best in interactive and stimulating online environments, which necessarily include self-regulating software. In episodic cluster headache, attacks usually occur daily in 6-12-week bouts (cluster periods) followed by remission periods. Changes in hyaluronidases in human saliva during the menstrual cycle.

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In such a setting, previous work has mostly concentrated on mixture modeling approaches. Since the growth of perovskite grains from a precursor solution tends to be more rapid with increasing Br content, further enhancement in the nucleation rate becomes necessary for the effective decoupling of the nucleation and the crystal-growth stages in Br-rich perovskites.

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Influence of plasma cholesteryl ester transfer activity on the LDL and HDL distribution profiles in normolipidemic subjects. Cardiac aminoacyl-synthetase and aminoacyl-transferring enzymes in normal and hypertrophied tissue. The relevant mechanism was also researched from the perspective of antioxidant effect and cholinergic system modulation. It was hypothesised that there will be significant levels of intergenerational continuity in antisocial behaviour when parents have ongoing contact with the child, and that stress from parenting and ineffective parenting styles will mediate this relationship. Average forces are well described by an implicit many-body potential, while pair models fail completely.

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Approximate parametric receiver operating characteristics for Poisson distributed noise. Detailed studies, particularly of the human NMNATs, have revealed distinct isoform-specific characteristics relating to enzyme kinetics and substrate specificity, oligomeric assembly as well as subcellular and tissue distribution. One hundred and five Thai women with breast pain who visited HRH Princess Maha Chakri Sirindhorn Medical Center were interviewed with breast pain.

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Consequently, similar convection effects may occur in other electrochemical nuclear magnetic resonance (EC-NMR) experiments, such as the electrochemical reaction of organic molecules, as well as in electrocatalysis/fuel cells, lithium-ion batteries, and experiments that use electrochemical electron paramagnetic resonance (EC-EPR) and electrochemical magnetic resonance imaging (EC-MRI). Histomorphologic analysis of cell aggregates showed that PRL induces the synthesis of proteoglycans and, in combination with glucocorticoids, a tissue structure with cells organized in longitudinal columns. Forskolin (PKA activator) and H-89 (PKA inhibitor) also individually increased mIPSCs frequency, with an additional increase induced by co-incubation with bilirubin and H-89.

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Comparative analysis of systemic and coronary hemodynamics during sevoflurane- and isoflurane-induced hypotension in dogs. This mixed methods study examined statements made by 459 grandmothers about core family relationships between grandmother and child, grandmother and parent, and parent and child.