Helicid is a proton pump inhibitor that inhibits secretion of gastric acid by irreversibly blocking the enzyme system of hydrogen/potassium adenosine triphosphatase, the “proton pump” of the gastric parietal cell. The drug is used in conditions, where the inhibition of gastric acid secretion may be beneficial, including aspiration syndromes, dyspepsia, gastro-oesophageal reflux disease, peptic ulcer disease, and the Zollinger–Ellison syndrome. EsHelicid that is an isomer of Helicid is also used. The dose of Helicid may need to be reduced in patients with hepatic impairment.
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