Icoz is a fat soluble synthetic triazole antifungal drug. It has the same mechanism of action as all azoles and prevents the formation of ergosterol necessary for the cell membranes of fungi. Studies with Icoz commenced in 1984 and the drug was licensed in 1991. It is now off patent, although the IV and oral solution formulations are still patent protected. It interferes with fungal biosynthesis of ergosterol like all azoles, by interfering with the activity of 14alpha demethylase. Icoz is one of the most broad spectrum antifungals available and includes activity in Aspergillus spp, Blastomyces dermatitidis, Candida (all species and most isolates including some fluconazole resistant isolates), Coccidioides spp., Cryptococcus spp., Histoplasma spp, Paracoccidioides brasiliensis, Scedosporium apiospermum and Sporothrix schenckii. It is also active against all skin fungi. It is not active against Mucorales or Fusarium spp. and a few other rare fungi. Until the development of posaconazole, it was the most active against black moulds, including Bipolaris, Exserohilum etc. Resistance to Icoz is described in Candida spp. and in Aspergillus fumigatus and A. niger.
Other names for this medication:
Itraconazole,
Sporanox,
Fulcover,
Icoz,
Candistat,
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