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Pharmacological inhibition of TREM-1 has proven effective in preclinical mouse models of infectious and non-infectious inflammatory disorders and malignancies, conferring survival advantages and protecting from organ damage or tumor growth by attenuating inflammatory responses. Purging of tumor cells from leukapheresis products: experimental and clinical aspects. There is only one reported case of which an aneurysm was believed to be the cause. Motor units initially firing at 30 Hz continued to fire tonically but at 15-20 Hz. To test the hypothesis that treatment with the angiotensin II type 1 receptor antagonist losartan would restore the normal dilation of the left main coronary artery to the cold pressor test in patients with essential hypertension, as assessed by echocardiography.

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Inhibiting PI3K/Akt pathway increases DNA damage of cervical carcinoma HeLa cells by drug radiosensitization. Two uncharacterised, independently isolated, embryo-lethal mycoplasmas obtained from turkeys and designated W8 and CT were compared with each other and with a third, culturally similar, embryo-lethal turkey mycoplasma, Iowa 695, by cultural and serological methods.

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Salivary actin and myosin abundances distinguish oral lesion types with sensitivity and specificity rivaling other non-invasive oral cancer tests. Rosetted glioneuronal tumor of the spine with overtly anaplastic histological features. The treated cohort evinced a higher prevalence of cardiovascular events, orthostatic hypotension, seizures, insomnia, and headaches.

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Torsional Failure of Carbon Fiber Composite Plates Versus Stainless Steel Plates for Comminuted Distal Fibula Fractures. We compared cortisol levels in scalp hair of shift and day workers to study changes in long-term cortisol due to shift work. Design, synthesis and alpha1-adrenoreceptor blocking activity of new arylpiperazines containing acetophenone substituents.

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Disease activity was ascertained with the Systemic Lupus Activity Measure (SLAM). However, the mechanisms underlying gastric carcinogenesis remain largely unclear. The result needs to be confirmed by performing similar studies at other institutions. In many US communities, HIV infection is the leading cause of death among young men and women, causing a large proportion of deaths in this age group.

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A critical finding was that during the course of the study, RhIL-12 did not induce a neutralizing antibody response to the administered cytokine. Both MCAs associated with VHL disease showed LOH with at least one of the microsatellite markers tested. Preferential utilization of uridine for nucleic acid synthesis, via the salvage pathway, was observed at the onset of germination, before the restoration of a fully functional de novo pathway.

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The 3-fold change is consistent with DNA release from an ordering interaction on the inside surface of the capsid at low pH values and suggests transitions that likely trigger the capsid for genome uncoating. Assembly of Agrobacterium phytochromes Agp1 and Agp2 with doubly locked bilin chromophores.

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These data indicate that a systemic immune response to any particular infectious agent is insufficient to induce enhanced atherosclerosis in the apoE-/- mouse and point to specific infections or immune mechanisms that might be essential for virally enhanced atherogenesis. The effect of keyboard keyswitch make force on applied force and finger flexor muscle activity.

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The effect of insulin and growth hormone on the flux of tracer from labelled lactate in perfused rat heart. With this approach, a library specific to the BTA 6q21-31 chromosomal region was constructed.

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Cartilage fibrils contain collagen II as the major constituent, but the presence of additional components, minor collagens, and noncollagenous glycoproteins is thought to be crucial for modulating several fibril properties. Both clonidine and guanabenz (from 10(-7) M) provoked a similar and clear inhibition (50-60 per cent) of MIX-stimulated lipolysis, compatible with the view that the alpha-adrenergic receptor of the hamster white fat cell is of the alpha-2 type.

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All three compounds were very well tolerated and no withdrawal symptoms were observed. Impaired modulation of sympathetic excitability by nitric oxide after long-term administration of organic nitrates in pigs. However, being a recipient of institutional care appeared to be a significant moderator in the longitudinal model.

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Total ankle replacement compatible with ligament function produces mobility, good clinical scores, and low complication rates: an early clinical assessment. High frequency of T cell clonal expansions in primary human melanoma. Total RNA was prepared from fibroblasts of two patients (ages 3-0.5/12 and 1-4/12 years) with delayed BA but normal growth curves. However, the mechanism by which tDCS exerts its effects on the cortex is not fully understood.

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Tinea capitis caused by Trichophyton tonsurans has been increasing in the United States for the past 25 years. Experience with scientific work organization at the therapeutic-prophylactic institutions of the Kalinin district Effect of sodium chloride, chlorite, and perchlorate on the hypochlorite-induced peroxidation of phospholipid liposomes. Weights, hematology, and serum chemistry of seven species of free-ranging tropical pelagic seabirds. The method, which is under consideration as the basis of an ISO standard, is described, and results are presented indicating how this concept of line-equivalent width can be used to compare different national standard flaws.

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One should consider targeted preventive interventions to increase the use of emergency contraception in groups at-risk for induced abortion. The controls on payments by insurance companies and governmental agencies (Medicare, Medicaid, Title 19) to hospitals have led to restricted hospital services for patients. Innovative approaches to the provision of care for these high-risk individuals will lead to improved patient outcomes. Avoidable late diagnosis of significant sensorineural hearing loss: implications for practice.

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We found that Akt was prolyl-hydroxylated by the oxygen-dependent hydroxylase EglN1. Bleeding diathesis in patients with mast cell activation disease. Quantitative high-throughput analysis of 16 (fluoro)quinolones in honey using automated extraction by turbulent flow chromatography coupled to liquid chromatography-tandem mass spectrometry.

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Prognostic value of perioperative near-infrared spectroscopy during neonatal and infant congenital heart surgery for adverse in-hospital clinical events. However, pathology test ordering is excessive and often unnecessary. The area of microemulsion isotropic region in the presence of ethanol was comparably larger in the absence of ethanol. The present case is rare with multiple compound odontomas involving both the jaws of 45-year-old male patient. LMP-1 effects on AP-1 are mediated through activation of the c-Jun N-terminal kinase (JNK) cascade, but not the extracellular signal-regulated kinase (Erk) pathway.

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(1) PSK suppressed in vivo artificial and spontaneous lung metastases of B16-BL6 in C57BL/6 mice. Functional annotation of rare gene aberration drivers of pancreatic cancer.

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Pelvic phlebography in determining the degree of spread of bladder cancer Autosomal dominant and recessive inheritance have both been reported, suggesting genetic heterogeneity, but most cases occur sporadically. In areas contaminated by radioactive materials, well designed dose assessment is necessary in order to protect people from radiation exposure and manage the exposure situation appropriately. Members of the sirtuin family including the founding protein Sir2 in Saccharomyces cerevisiae have been linked to lifespan extension in simple organisms. Molecular properties of hepatic uptake systems for bile acids and organic anions.

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The isodose distribution was depending of the tissue infiltration of the tumor. A Comparison of Resources for the Annotation of a De Novo Assembled Transcriptome in the Molting Gland (Y-Organ) of the Blackback Land Crab, Gecarcinus lateralis. It is expected that new and more informative criteria for diagnostics, treatment,and prognosis of laryngeal papillomatosis will be proposed based on recent progress in molecular biology, morphology,and immunology. Intracranial pressure in patients with ruptured saccular aneurysm. On the other hand, other methods use combined extraction techniques, and even additional derivatization steps in order to increase the sensitivity and accuracy of the analysis.

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Short-term glucocorticoid treatment effectively abolished the catabolic effects exerted by the combination of pro-inflammatory cytokines and mechanical injury: dexamethasone prevented proteoglycan degradation and restored biosynthesis. Tumor fluid contained significant erythropoietic stimulating activity. An online survey including 5 peripheral nerve entrapment clinical scenarios (2 upper extremity and 3 lower extremity) was administered to medical students and primary care providers at a large academic medical center.

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The geriatric population is the fastest growing segment of the population, and geriatric trauma patients are increasingly common. The nidus volumes ranged from 0.3 to 11.1 cm(3) (median 3.2 cm(3)). Internet use and its relation with the psychosocial situation for a sample of university students. The purpose of the present experiment was to study the way in which the central nervous system (CNS), represents gravitational force during vertical arm pointing movements. This combination of techniques provides a uniquely sensitive approach for studying changes that occur upon protein adsorption at an interface.

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Tellurite-reduction-based assay for screening potential antibiotics. Current research into serologic methods of diagnosis shows great promise for better classifying patients, which ultimately will facilitate treatment. These results indicate that the autoregulatory feedback mechanism of circadian oscillation of the period gene may also be conserved in mammals. The response profiles of all types of sensilla trichoidea in the two species well matched the specificities of the pheromone receptors (PRs) expressed in the same sensilla, as measured in voltage-clamp experiments. Projection method formulations of Hopfield-type associative memory neural networks.

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Mono-(1), di-(2, 3) and tetra-(4, 5) cationic pyropheophorbides are soluble as an oligomeric aggregate in HEPES buffer, but hexa-(6) cationic pyropheophorbide is soluble as a monomer at lower concentrations. A unified explanation for the diverse structural deviations reported for adult schizophrenics with disrupted speech. Structure-based virtual screening of the nociceptin receptor: hybrid docking and shape-based approaches for improved hit identification.

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During post-training brief-access taste tests, GvF rats licked more for glucose than for fructose, whereas the other training groups did not respond differentially to the two sugars. These rat lines differ not only in their gnawing response to apomorphine, but also in their behavioral response to novelty (APO-SUS: high, APO-UNSUS: low).

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To compare computed tomography (CT) images of equine tarsi with cross-sectional anatomic slices and evaluate the potential of CT for imaging pathological tarsal changes in horses. The primary purpose of this study was to compare energy expenditure among resistance exercise protocols using maximally explosive or slow contractions versus recreational in trained and untrained men. The effects of computer-based fire safety training on the knowledge, attitudes, and practices of caregivers.

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The optimal cut-off value of tumor size to predict the risk of CLNM in papillary thyroid microcarcinoma was 0.575 cm (area under the curve 0.721) according to the ROC curves. It is our impression that patients with IPH, benefit from long-term steroid treatment which in turn results in a milder course. Self-efficacy and related but distinct theories that underpin behaviour change are discussed. No relationships were observed between cortical thickness and the severity of anxiety symptoms in the significant regions that were identified in the vertex-wise analysis.

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Factors influencing work interference in patients with chronic low back pain: a Residency Research Network of Texas (RRNeT) study. In experimental systems, interference with coagulation can affect tumor biology.

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Capillary refill time (CRT) has been taught as a rapid indicator of circulatory status. Disruption of the remaining ORFs did not result in readily detectable phenotypic changes.

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The triple A syndrome gene, designated AAAS, is localized on chromosome 12q13. Other secreted factors including ciliary neurotrophic factor and ghrelin have also been shown to regulate energy metabolism.

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Thus, spinal AADC neurons have the enzymatic capacity to catalyze directly the conversion of the amino acids tyrosine, tryptophan, or phenylalanine to their respective amines tyramine, tryptamine, or phenylethylamine. Histones and RNA synthesis: selective binding of histones by a synthetic polyanion in calf thymus nuclei.

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Longer assessment periods across disease stages will help map this progressive trajectory. Lung ventilation/perfusion SPECT in the artificially embolized pig. This situation finds its expression in the fact that such working people are forced out of commercial activity, at the latest upon reaching the retirement age.

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In the SAPNS-treated animals the graft of SAPNS integrated well with the host tissue with no obvious gaps. Uncomplicated biliary colic is one of the commonest indications for laparoscopic cholecystectomy. They were found to be able to distinguish between the two states. Do endogenous volatile organic chemicals measured in breath reflect and maintain CYP2E1 levels in vivo?

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The results herein provide insights of how big dams have disrupted the sediment conveyance processes of large scale fluvial systems. At 48 weeks, plasma lipid concentrations were lower with atazanavir/ritonavir than with other ritonavir-boosted protease inhibitor regimens. A comparison between bottom-up and trial-and-error approaches is performed for all the discussed elements and mathematical models supporting the prediction of parts behaviour are illustrated. The CT and PAI contrast-enhancing effects were tested and then compared with a clinically used CT contrast agent and Au nanoparticles.