Norbactin is usually efficacious for urinary tract infections (curing rates about 90%). Compared to amoxicillin it is a little more efficacious; compared to co-trimoxazole or ciprofloxacin the results are equal. Norbactin is particularly suited for complicated and therapy resistant urinary tract infections. As the drug reaches high concentrations in the prostate tissue, it is also suited for the treatment of prostatitis. Like with other drugs, the duration of treatment has to be fairly long (4 weeks). For the treatment of an uncomplicated gonorrhea (urethritis or cervicitis) a single Norbactin dose of 800 to 1200 mg is effective. ß-lactamase producing neisserias can thus be treated with similar success as with spectinomycin. Resistant gonococci are rare. Numerous enteric infections can be treated with Norbactin: similarly to e.g. co-trimoxazole or doxycycline, the drug is suitable for the prevention of diarrhea; it is also effective against salmonellosis. Norbactin can prevent Gram-negative infections in granulocytopenic patients. In the form of eye drops, Norbactin is effective against bacterial conjunctivitis and other surface eye infections.
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