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Spirix (Spironolactone)

Spirix is a potassium sparing diuretic like eplerenone that competitively inhibits mineralocorticoid receptors in the distal convoluted tubule to promote sodium and water excretion and potassium retention. Spirix was originally developed purely for this ability before other pharmacodynamic properties of the drug were discovered. It is indicated to treat a number of conditions including heart failure, deem, hyperaldosteronism, adrenal hyperplasia, hypertension, and nephrotic syndrome. Off label uses of Spirix involving its antiandrogenic activity include hirsutism, female pattern hair loss, and adult acne vulgaris. Spirix is also frequently used in medical gender transition. Spirix was developed in 1957, marketed in 1959, and approved by the FDA on January 21, 1960.

Other names for this medication:
Spironolactone, Aldactone, Aldactazide, Aldactazine, Aldazida, Aldazide, Aldozone, Alexan, Alizar, Carpiaton, Espirone, Espironolactona, Expal, Kespirona, Lanx, Letonal, Osiren, Osyrol, Practon, Prilactone, Spiractin, Spiresis, Spirix, Spiroctan, Spirolang, Spirolon, Spiron, Spirono, Spironolacton, Spironolactona, Spironolakton, Spironolattone, Spirotone, Verospiron, Xenalon,

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This study demonstrates the potential for use of IL-1 as an auxiliary in combinations with chemotherapeutic agents and radiation. The percent change in performance relative to the single-task condition was calculated and defined as the dual-task cost. Arthritis also exhibits a significant, positive association with killing/causing severe injury.

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Although the muscle mass of the grafted hindlimb at E18 was significantly less than that of the normal hindlimb (and similar to that of a normal forelimb), electronmicroscopic examination of the grafted hindlimbs and brachial spinal cords of E20 embryos revealed normal myofiber and neuromuscular junction ultrastructure and a small increase in the number of axosomatic synapses on cross-sections of motoneurons innervating grafted hindlimbs compared to motoneurons innervating normal forelimbs. Patients referred for gastroscopy directly (open access) or after consultation with a gastroenterologist, by physicians in the departments of internal medicine and surgery at a major tertiary center, were compared for indications, background disease, outcome and diagnostic yield.

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5 -pregn-9(11)-ene-3 ,6 -diol-20-one and 5 -cholesta-9(11),20(22)-diene-3 ,6 -diol-23-one. We sought to determine the impact of rural LICs in terms of practice location of graduates.

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Fully Balanced Fluids do not Improve Microvascular Oxygenation, Acidosis and Renal Function in a Rat Model of Endotoxemia. The inducibility of tyrosine aminotransferase in monolayer cultures of hepatocytes from neonatal rats.

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The stress of Stroop performance: physiological and emotional responses to color-word interference, task pacing, and pacing speed. The rates, per 1,000 resident children, were compared with socioeconomic indices for the boroughs concerned. We propose this rearrangement of the water network to be another possible mechanism of allostery. Caring for uninsured patients with diabetes: designing and evaluating a novel chronic care model for diabetes care. The enhanced production of this antigen by chlamydiae as a result of iron limitation is of particular importance since there is a well-documented association between chlamydial hsp60 and destructive immunopathological sequelae in infected patients.

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The relationship of the major Omp of Pasteurella multocida and OmpC and OmpF had been verified in recent studies. The purpose of this study was to evaluate disease control and survival after stereotactic brachytherapy in patients with circumscribed and relatively small size tumors. Carotid stenting has been demonstrated to be technically feasible and safe in high-risk patients. Using streptolysin O-permeabilized cells we confirmed regulatory function played by dephosphorylation of tyrosine residues in capping of Fcgamma receptor II.

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The survey form was composed of 29 self-administered questions frame based on knowledge, attitude, and those regarding the practices of dentists in relation to dental health-care waste management. Kaplan-Meier estimators and a Cox proportional-risk model were employed. Acute peritoneal dialysis in the newborn period: a 7-year single-center experience at tertiary neonatal intensive care unit in Turkey. We present several examples to illustrate the capability of the proposed model.

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From recommendations made by teachers and multiple agencies, the modified 3-day program was approved to implement on a yearly basis in all public elementary schools in Miami-Dade County. Although the technique is able to recover secreted materials only at the 5-10 cell level, the detection system has a limit of detection (LOD) in the attomole (10(-18) M) range. Renal outcome and risk factors for end-stage renal disease in pediatric rapidly progressive glomerulonephritis.

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Limited research has been undertaken to assess the effectiveness of pre-hospital care given at the point of wounding, nor how battlefield conditions affect the implementation of Battlefield Advanced Trauma Life Support (BATLS). The age decade during which the greatest number of pacemaker implantations was carried out was the 70s, followed by the 80s. In this study efficacy expectations were important to determine fat and fiber consumption. The HS diet promoted hepatic lipid accumulation by suppressed lipolysis in the peroxisomes and normal levels of VLDL secretion. ALP has been demonstrated recently to induce mineralization of collagen sheets in the animal body.

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Connotative meaning of concepts related to cleft lip and palate. Requirement of NifX and other nif proteins for in vitro biosynthesis of the iron-molybdenum cofactor of nitrogenase. The results indicate that transcription of cspA and cspB increased during each temperature downshift and consistently decreased after each temperature upshift. Eight rabbits from the control group and two rabbits from the experimental group had necrosis in fatty bone marrow.

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Two sites of the promoter region and two sites of the enhancer region of the OTC gene, as well as the ovalbumin promoter site, were recognized by both HNF-4 and COUP-TF, showing that these two factors have closely related binding specificities. The ESR-CT imaging technique is considered to be a powerful new tool for noninvasive investigations of the in vivo spatiotemporal dynamics of free radical distribution and elimination in the organs.

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In an experiment, after a rest period, subjects were studied during a neutral interview and a stress interview. Leydig cell apoptosis in the rat testes after administration of the cytotoxin ethane dimethanesulphonate: role of the Bcl-2 family members. The heart rate decreased by about the same magnitude after all the compounds tested, suggesting that the cardioselectivity of metoprolol was the likely explanation for its differing response from propranolol.

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Estimation of protein concentration at high sensitivity using SDS-capillary gel electrophoresis-laser induced fluorescence detection with 3-(2-furoyl)quinoline-2-carboxaldehyde protein labeling. Primary, intermediate and tertiary levels of care are represented, but not always in a logical relationship to community needs. Most experience pertains to angioedema resulting from C1-inhibitor deficiency, and the controlled studies have focused on the hereditary form of this disease type (HAE).

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The potential offered by intensive and strategic adoption of information and communication technologies for obtaining advances in the health sector is worldwide recognized. A reaudit of current febrile neutropenia practice in UK paediatric oncology centres prior to implementation of NICE guidance. In isolated tissue systems, its potency ranked as follows: guinea pig ileum, mouse vas, rabbit vas, and rat vas. fleas, flies and mosquitoes) are spin-offs from agrochemical research and development.

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Patients with and without anxious depression demonstrated similar rates of improvement in depression. The proapoptotic effects appear to be linked to pathophysiological conditions, where high concentrations of NO are produced by the inducible nitric oxide synthase, especially in macrophages. Instead, our data suggest that a number of aromatic residues in the SET domain contribute to the formation of an active site that facilitates substrate binding and dictates product specificity.

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The effect of posterior lobe extracts on prolactin secretion in vitro was compared with that of median eminence, hypothalamic (with and without median eminence) and cortex extracts. The question of the extent to which n-3 fatty acid supplementation reduces risk for cardiovascular disease remains open.

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15) Two- or four-week repeated-dose studies and fertility study of bromocriptine in female rats. We investigated the accommodative hysteresis of the refractive error in the light and also in the dark in 19 healthy young women. We describe an isolated complete pancreatic transection in a 14-year-old female secondary to a previously unreported and highly unusual mechanism (being tossed by a wave). Currently the LCP Central Team coordinates LCP implementation and dissemination for all international collaborating countries except New Zealand, from its base in Liverpool in the UK.

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A high proportion of these bacteria were resistant toward one or several heavy metals and metalloids including As, Cu, and Zn, the most abundant in plant tissues and soil. Jimma University Hospital (JUH) in south west Ethiopia has been running an integrated rural chronic disease programme since 1999, focusing on treatment of epilepsy, diabetes and heart disease. To validate them, nutritional scores should be compared with clinical outcomes. Dispersive electrode temperature rise is also critically determined by the sub-surface skin anatomy, thicknesses of the subcutaneous and supra-muscular fat, etc.

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Most of our knowledge of hematopoietic stem cells is from animal models in which purified stem cell canididates are assayed based on their functional ability to rescue lethally conditioned recipients. SPM1 is a single-copy gene, encoding a subtilisin-like serine protease with 536 amino acids.

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One application is the manipulation of small objects within liquid, which is the focus of this review. The observed antioxidant activity of the extracts from the four investigated medicinal plant species was dependent on both the solvent used for extraction and the assay method (conventional or biosensor-based). Adoptive transfer of normal T cells loaded with oncolytic virus into individuals with cancer would be technically easy to implement both to reduce the distribution of metastases and to vaccinate the affected individual in situ against micrometastatic disease. The WST-1 assay was used to detect the cytotoxic effect of antibiotics. We describe the proposed solution, along with its advantages and tradeoffs.

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Salinomycin induced no essential changes in the slaughter indices and in the content of cyanocobalamin in the meat. We find that LEP-2 post-translationally regulates LIN-28 by promoting LIN-28 protein degradation.

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When IL-3 was located at the amino domain of the protein, induction of erythroid colonies was similar to that of a mixture of IL-3 and Epo. Alternative therapies such as acupuncture have shown benefits in limited studies. More recently, nebulized adrenaline demonstrated a short-term benefit. This technique was applied in 20 consecutive patients with emphysema who underwent a unilateral lung volume reduction operation via a thoracoscopic two windows approach.

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Image recovery from data acquired with a charge-coupled-device camera. This report documents the case of a patient with JIA who improved following a switch from etanercept to infliximab.

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Ecuadorian scorpion fauna remains one of the less well studied among those of South America. Physical factors affecting microencapsulation by simple coacervation of gelatin. Serum levels of IgG subclasses and vitamin A in children with recurrent respiratory tract infection Starch is the main component in the wheat endosperm and exists in two forms including A- and B-type granules.

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Specific 16S rDNA sequences associated with naphthalene degradation under sulfate-reducing conditions in harbor sediments. This proof-of-concept analysis showed that circulating tumor DNA is an informative, inherently specific, and highly sensitive biomarker of metastatic breast cancer. Briefly stated, the model proposes job control to be a primary causal determinant of the stress outcomes.

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In order to locate the two GS mutations, samples were collected from 11 people from two different pedigrees for direct genetic sequencing and comparison of the 26 exons of SLC12A3. The comparative sequence analysis of the E2 region revealed two main phylogenetic groups of CSFV, indicating that the virus apparently evolved from two ancestor nodes.

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SWE reflected mainly inflammation, whereas Instron machine-derived values primarily reflected fibrosis. Conversely, having a more mindful predisposition was associated with less frequent use of compensatory strategies, especially for middle-aged adults. As a result, flow cytometry is becoming the leading technique used in this area of research. Topical FK 506 (tacrolimus) and steroids have been used in clinical VCA as an adjunct to systemic therapy with unclear beneficial effects.

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Detection of a novel active transposable element in Caldicellulosiruptor hydrothermalis and a new search for elements in this genus. It has been suggested that LTA and VASP-P assay correlate differently according to the level of P2Y12 receptor blockade by thienopyridines. In anesthetized rats, manual acupuncture-like stimulation of the cheek, forepaw, upper arm, and hindpaw increases the cortical cerebral blood flow (CBF). Anisotropic conductivity rotates heat fluxes in transient regimes. We found a reduction in overall CDRI scores, ie, improved health profiles, for both men and women over time.

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To examine patterns of use of preoperative beta-blockers in patients undergoing isolated CABG and to determine whether use of beta-blockers is associated with lower operative mortality and morbidity. The comparison of exon structures of COL19A1 and other FACIT family genes revealed several similarities among these genes. To determine if the cytokine antagonists interleukin-1 receptor antagonist (IL-1ra) and tumor necrosis factor-binding protein (TNF-bp) alter host resistance mechanisms they were evaluated in a rodent abscess model. Linkage analysis of X-linked mental retardation with and without fragile-X using factor IX gene probe.

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Immediately following, and 30, 60, 90, and 120 min after the self-administration session, expired carbon monoxide levels and typical symptoms of nicotine withdrawal were assessed. Under physiological circumstances, cell membrane damage is not evident in biliary systems, despite the fact that hydrophobic bile salts are known to induce such damage by their detergent effects. The male in vivo battery will be used to assess several different types of endocrine activity, primarily by using a comprehensive hormonal battery.

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Blood treated with ethylenediaminetetraacetic acid (EDTA) exhibited platelet activation both pre- and postagitation but activated platelets did not cause platelet aggregation. The authors correlated and presented clinical, radiological and pathological findings in 6 patients with Adult Respiratory Distress Syndrome (ARDS): It is a distinct syndrome with characteristic clinical, radiological presentations and pathological findings. Cochlear implantation can be an effective method of hearing rehabilitation in patients with petrous bone cholesteatoma, following total eradication of disease, if the cochlea remains intact.

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Associations of erosive arthritis with anti-cyclic citrullinated peptide antibodies and MHC Class II alleles in systemic lupus erythematosus. There has been an ongoing interest in the analysis and comparison of the efficiency of health care systems using nonparametric and parametric applications. A 68-year-old woman had suffered open fracture of her right tibia 2 years prior, and a split-thickness skin graft had been applied to repair the skin defect on the right tibia. Empty screw holes after hardware removal are stress risers that weaken bone and can lead to refracture in an active individual. Full clinical and biochemical recovery occurred in all patients.

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Use of a purified and functional recombinant calcium-channel beta4 subunit in surface-plasmon resonance studies. Effects of dietary arachidonate deficiency on the aggregation of cat platelets. Thus, large T and small t antigens, the products of the simian virus 40 early region, are not produced when the virus infects embryonal carcinoma cells, in contrast to other cell types. Performance and welfare of laying hens in conventional and enriched cages. In all, after insertion of sclerotic agents, CBCT was used to observe distribution of the sclerotic agent in the gastric varices and afferent gastric veins.

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Additionally other physicochemical substituent-properties may play a major role. On the other hand, the anticholinesterase, physostigmine, potentiated both the vasopressin-induced tonic and spontaneous contractions. The TSC-2 product tuberin is expressed in lymphangioleiomyomatosis and angiomyolipoma. The role of immunosuppressive therapy in ulcerative colitis remains controversial. Spore loads of Paranosema locustae (Microsporidia) in heavily infected grasshoppers (Orthoptera: Acridoidea) of the Argentine Pampas and Patagonia.

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This makes CSS vesicle a promising carrier for the treatment of cancer, especially for leukemia. Neither papilla formation nor hypersensitive cell death occurred under the conditions tested. This review places emphasis on relating up-to-date biochemical facts to the physiological realities of the smooth muscle cell.

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Combined with relevant clinical data, we analyzed the PB morphologic features in all the FUO patients. Long-term clinical effects of transitioning to the lower dose have not been evaluated.

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One poorly differentiated (CTP) thyroid cell line secreted IL-1 beta, IL-6 and IL-8. Microdialysis fibers were inserted into the dermis in the lower leg in male healthy volunteers. This study aimed to verify the adherence, knowledge and the difficulties of elderly patients with Bipolar Affective Disorder (BAD) in relation to the prescribed pharmacological therapy for the control of this disorder. This group of patients characterized lower antioxidation activity than other groups.

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In vitro, there was reduced binding of mutated Syk to phosphorylated ITAM due to this increased phosphorylation. Topical timolol could be an effective treatment for reduction of myopic regression especially the spherical errors after myopic LASIK. We investigate the propagation of high energy laser beams through vaporizing metallic aerosols in the regime for which plasma generation becomes important. Nowadays, composite catalysts are being used more and more to meet the practical catalytic performance requirements in the chemical industry of high activity, high selectivity and good stability.

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However, standard stepped-care therapy with diuretic drugs and beta-blocking agents is now under reevaluation in view of the potential adverse effect of these agents on serum lipids and renal function. Finally, we discuss the development of new drugs, selective AR modulators, for treating the metabolic syndrome in men.

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Features noted included age at onset of visual symptoms, presence of photophobia, visual acuity, and electroretinogram findings. Causes and treatment of anesthesia complications in oral and jaw surgery Northern analysis of K562 cell mRNA revealed that eIF-2 beta was five times more abundant than eIF-2 alpha. Specific strategies are aimed at interference with the action of particular drugs of addiction. Investigation of promoter variations in dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN) (CD209) and their relevance for human cytomegalovirus reactivation and disease after allogeneic stem-cell transplantation.

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Thus, thrH encodes a protein with an in vivo homoserine-kinase-like activity. Myriad Functions of Stanniocalcin-1 (STC1) Cover Multiple Therapeutic Targets in the Complicated Pathogenesis of Idiopathic Pulmonary Fibrosis (IPF).

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Research on this lovire 400 tablets aciclovir tablets field needs to be redirected in a prospective manner in order to evaluate risk models in the emergency department. A total of 48 patients underwent modified midfacial translocation at our institution for nasopharyngeal, parapharyngeal, and anterior, central and lateral skull base tumours. Lipid-lowering drugs and heart failure: where do we go after the statin trials? In this paper we review the INLA approach and present some applications on spatial and spatio-temporal data. The blood supply of the papillary muscles of the left ventricle in the Hereford cattle.

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Adenosine is a safe and effective agent for treating preterm infants with SVT. Thus, we believe theoretical and empirical arguments favor these methods as the preferred atheoretical indices of delay discounting. Furthermore, DGGE analysis price of lansoprazole 30 mg showed that sequences from prominent bands were affiliated to members of four major phyla of the domain Bacteria: Cyanobacteria, Bacteroidetes, Proteobacteria, and Actinobacteria, most of which corresponded to heterotrophic bacterial populations involved in carbon, sulfide, and nitrogen biogeochemical cycles, which were indistinguishable under the light microscope.

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NPWT not only removes fluid, and reduces oedema, but also promotes perfusion around the wounds. calutol de 50 mg Effect of alpha-adrenergic blockade on exercise-induced asthma and conditioned cold air. In this study, the extent to which such information can be directly extracted from the mass spectrometric data used for identification was evaluated.

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Impact of Angiotensin-II receptor blockers on vasogenic edema in glioblastoma patients. Pharmaconutrition: acute fatty acid modulation of circulating cytokines in elderly patients in the ICU. Targeted phototherapy with single-wavelength laser light is a treatment alternative that may prove to be a time-efficient and effective herpesil 200 mg posologia de medicamentos therapeutic option for the management of vitiligo. Thresholds for the perception of rotation: variability, psychometric curves, and comparison with hearing thresholds.

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Upper-limb movement classification based on sEMG signal validation bactrim coverage of mssa pneumonia with continuous channel selection. Sex/gender differences in the brain and cognition in schizophrenia. Glomerular ultrafiltration of macromolecules is a biophysical process sharing both a diffusive and a convective component, governed by glomerular hemodynamics, through a composite structure, the glomerular filtration barrier.

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Despite the fact that impact force and exposure time to dusty gas declined toward PDCs periphery up to the survival conditions, lethal temperatures were maintained up to the PDCs extreme depositional limits. The most probably explanation seems to be a combination of many improvements in the quality of care, with increased awareness of risks, better selection of high-risk prospect rispen 2 mg groups, and improved supervision and management throughout. Phonological codes and functional spelling units: reality and implications. Effects of carvedilol and atenolol on arterial pulse curves (plethysmography) and finger temperature after hand cooling.

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Hereditary angioneurotic edema, although a rare clinical entity, can be fatal if diagnosis and appropriate therapy are not instituted before the performance of routine dental and oral surgical procedures. ABC transporters represent one of the lamotrigine medication assistance largest families of membrane proteins that are found in all three phyla of life.

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Using an electronic picture processor an analog representation of isobaric ace mol 100 mg gabapentin areas is obtained and evaluated, thereby integrating the areas of equal optical density. Continuous diagnostic tests are often used for discriminating between healthy and diseased populations.