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Topimax (Topiramate)

Topimax was first approved in the United States in 1996 for treatment of epilepsy. Topimax has gained additional approvals for treatment of migraine headaches and, in combination with phentermine, for weight loss. Topimax has high bioavailability and low binding to serum proteins. Salivary Topimax levels correlate well with plasma/serum concentrations, making saliva a viable specimen for TDM. Approximately 50% of the absorbed dose is metabolized by the liver. Inhibitors and inducers of liver drug metabolism can significantly alter the serum half-life of Topimax in adults from 20–30 h to 12 h. Children typically clear Topimax faster than adults.

Other names for this medication:
Topiramate, Topamax, Epitomax, Letop, Neutop, Piramax, Talopam, Topamac, Topictal, Topigen, Topilex, Topimax, Topina, Topiramato, Topirol, Toplep,

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The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword. In addition, stress-induced behavioural changes in prefrontal cortical dopamine-depleted rats were significantly reduced following selective discrete infusions of a D2 dopamine receptor antagonist into the NAc shell. While necessary for the performance of hysteroscopy and hysteroscopically-directed procedures, distending media, if absorbed systemically in sufficient amounts, can have associated adverse events, including life-threatening complications.

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Subsequently, the number of accumulated leukocytes decreased in the P-selectin-inhibited rats. Antiviral effect of 3, 4-dihydro-1-isoquinolineacetamide hydrochloride in experimental human rhinovirus infection. An Empirical Study of Neural Network-Based Audience Response Technology in a Human Anatomy Course for Pharmacy Students. A longitudinal and predictive study of 100 participants in the heart care unit of a county hospital in southern Sweden was performed.

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Observational studies (clinical epidemiological studies) based on public registers and clinical databases have shown good agreement with the results from RCTs. All of them had been preoperatively studied by oesophagogastroscopy and computed tomographic scanning of the chest which had confirmed the presence of a lesion with benign features. When stably introduced into primary erythroblasts or conditionally transformed erythroid progenitors cells, exogenous GATA-2/ER promoted proliferation and inhibited terminal differentiation in an estrogen-dependent manner. New knowledge on HLA class II molecules and a better selection of organs for transplantation An aspiration catheter is used to remove trapped emboli after stenting and before occlusion balloon deflation.

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Studies were conducted to investigate the hypothesis that N-nitrosodimethylamine (NDMA) is a potential disinfection by-product specifically produced during chlorination or chloramination. EXTRAVASCULAR AND INTRATUBULAR DIFFUSION OF LABELED SERUM PROTEINS IN THE RAT TESTIS. This unblinded study was undertaken to determine whether PLDD would alleviate the pain of spinal stenosis in patients who also had protruding lumbar discs. Baseline plasma PS concentrations are not associated or predictive of changes in serum cholesterol or plasma PS concentrations after PS intervention.

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Moreover, the influence of familial factors (genetics and family background) on the associations are mainly unknown. Actin cytoskeleton plays a critical role in regulating T cell motility and activation.

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These isolates were thymidine-kinase-deficient mutants and were isolated within a week of discontinuation of a 1 week course of acyclovir therapy. Dehydroepiandrosterone is produced by both the ovary and adrenal, as well as being derived from circulating DHEAS. Isoniazid (INH) is one of the main first line drugs used in treatment of tuberculosis and development of resistance against this compound can result in serious problems in treatment procedures. This assay allows for delineation of potential mechanisms of action a compound of interest has, as one can determine whether or not a cancer cell that is being treated with the potential drug has changes in proteolytic activity and/or migratory ability at the same time. Specific effects of various catecholamines as well as functional dependence of mitochondrial enzymes activity on catecholamine metabolism were studied.

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What is the current role of radiation therapy in the treatment of skin carcinomas? Both are motoneurons located in the buccal ganglia of the snail Lymnaea stagnalis where they participate in feeding behavior. Needle syringe programs (NSPs) are now on a strong platform mainly because of their crucial role in controlling/containing blood-borne virus infections. Various parental factors are associated with childhood overweight and physical activity. These data also confirm the feasibility of using computerized psychoeducation and speak to the importance of providing education to both acute and chronic patients across settings.

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Principal components analysis of the mass spectrometry-based urinary metabolic profile showed that alcohol-treated wild-type and Ppara-null mice could be distinguished from control animals without information on history of alcohol consumption. The summary in this chapter is not exhaustive, but should provide a good preparation to those wishing to use this highly successful gene expression system. Baclofen-potentiated acid secretion induced by direct vagal stimulation was not affected by the change of body temperature.

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Identification of early S phase nuclei by observation of centriole replication in cultured human lymphocytes. Attending support groups connects adults undergoing bariatric surgery to peers and may improve weight loss efficacy.

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The effect of invasion rate, species pool, and size of area on the structure of the diatom community. To measure the prevalence of, and factors associated with, left ventricular (LV) dysfunction in systemic sclerosis (SSc). Here we use these phosphoantibodies to demonstrate the existence of tyrosine-phosphorylated ErbB2 subsets which differ in their patterns of heterooligomer formation, in vitro autophosphorylation, and recruitment of SH2-containing substrates. Evaluation of cerebral circulation and oxygen metabolism in infants using near-infrared light.

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High altitude, continuous positive airway pressure, and obstructive sleep apnea: subjective observations and objective data. We found no statistically significant relationship between traumatic cannulations and the development of symptoms of carpal tunnel syndrome. This study demonstrates the utility of strand-specific sequencing in generating shotgun transcriptomes and that rapid sequencing shotgun transcriptomes is possible without the need for extensive inbreeding to generate homozygous lines.

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The adsorption of enkephalin to porous polystyrene beads: a simple assay for enkephalin hydrolysis. Responding to such incidents requires an ever-evolving approach as no two incidents will present exactly alike.

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Utilization of GSH in both enzymic and non-enzymic defence mechanisms results in its conversion to the oxidized form (GSSG), and it must be recycled to GSH to maintain the high intracellular ratio of GSH to GSSG. The obstruction of a bowel segment at two points results in closed-loop obstruction, and is apt to cause strangulation.

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Results of survival models applied to nationally representative sample of never-married young men aged between 15 and 24 obtained from the Demographic and Health Survey data show that being circumcised is associated with earlier initiation of sexual activity in Malawi. Administration of adrenergic alpha 1 and alpha 2 receptor agonists (noradrenaline, phenylephrine, clonidine) produced behavioral excitation in the open field test and a tendency to decrease the forebrain 5-hydroxyindolo-acetic acid (5HIAA) concentration. Synthesis of four protected peptide fragments corresponding to parts of the N-terminal 1-17 sequence of rat pancreatic ribonuclease.

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Surface alterations characteristic of stratified metaplasia were observed. Kinetic studies of the inhibition of muscle phosphorylase phosphatase.

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Furthermore, surfactant distribution was not affected by length of mechanical ventilation. De novo transcriptome assemblies of RNA-Seq data are important for genomics applications of unsequenced organisms.

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longicaudatus, Paratrichodorus minor, Tylenchorhynchus sp., and Mesocriconema sp. The patients whose recurrent tumor(s) did not meet all 4 of these factors showed a better prognosis. Socioeconomic status disparities in adolescent psychological distress were evident and consistent during the 6-year period. A questionnaire on the proposed diagnostic evaluation of seven case reports, each accompanied by relevant imaging, was distributed by e-mail to members of the International Society for Pediatric Neurosurgery, the European Society for Pediatric Neurosurgery, and via the PEDS server list between March and August 2008.

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RBD were not found, whereas the neuropsychological assessment revealed a progressive cognitive impairment. Biomarkers of human exposure to personal care products: results from the Flemish Environment and Health Study (FLEHS 2007-2011). This unique aconitase relationship is not observed in other mammalian cells.

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Participants were offered (1) a basic introduction to QI methods, (2) the option of an alternative Part IV MOC module using a patient experience survey to guide QI efforts, (3) practice-level improvement coaching, (4) support for collaboration and co-learning, and (5) provision of QI resources. All subjects underwent breath-hold two-dimensional (2D) time-of-flight MR venography using a fast low angle shot (FLASH) technique with a 1.5 Tesla magnet.

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Structural and functional analyses indicate that mutant STING enhances homodimerisation in the absence of its ligand cGAMP resulting in constitutive type I IFN activation. Hemodynamic and cardiac effects of the selective T-type and L-type calcium channel blocking agent mibefradil in patients with varying degrees of left ventricular systolic dysfunction.

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In addition, the pitch and diameter of the patterns are found to significantly influence their adhesion/friction behaviors. Here, methods of construction for several biomass constituting equations are reviewed along with potential changes to cellular composition with potential biofuels exposure. Progress in the Development of non-BET Bromodomain Chemical Probes.

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While textual data can be easily de-identified, patient data in medical images implies a more elaborate approach. Two additional samples were collected during chemoradiation therapy and a final sample was collected at the end of chemoradiation therapy.

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Species delimitation using a combined coalescent and information-theoretic approach: an example from North American Myotis bats. In contrast to the theoretical assumptions, a recent meta-analysis provides evidence that neither culture, nor gender, influences the association between dyadic coping and relationship satisfaction, at least based on their samples of couples living in North America and West Europe. In this study, we report changes to circular DNA conformation from intercalation with ethidium bromide using all-atom molecular dynamics simulations and characterized experimentally by translocation through a silicon nitride solid-state nanopore. Enhanced collagen production and accumulation by smooth muscle cells.

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Teenage pregnancy and its effect on maternal and child health--a hospital experience. Surgical treatment of traumatic facial paralysis with substance loss with tantalum thread Insulin and insulin-like growth factor-I acutely inhibit surface translocation of growth hormone receptors in osteoblasts: a novel mechanism of growth hormone receptor regulation. Because supplemental oxygen therapy did not increase hospital resource utilization, we recommend prescribing oxygen therapy to patients with OHS who meet criteria with close monitoring.

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Information on thorotrast dosimetry supplied by the radiochemical analysis of tissue specimens. A theoretical model for EM-ML reconstruction algorithms applied to rotating PET scanners. MS3ALIGN: an efficient molecular surface aligner using the topology of surface curvature.

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The involvement of an opiate mechanism in the sensitized behavioral deficit induced by early chronic variable stress: influence of desipramine. After exponential growth for 4 h, the population of fibronectin-attached S. Understanding the Experience of Age-Related Vestibular Loss in Older Individuals: A Qualitative Study.

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Intravitreal Bevacizumab for Choroidal Neovascular Membrane at the Edge of a Healed Choroidal Tuberculoma. The aim of this article was to present the areas of research on nutrition in Polish preschool children based on the review of the literature, and to present and summarise the results of the studies on the assessment of preschool menus. This paper describes hearing loss and recovery as well as cochlear damage in chicks, after a 200-h exposure to an intense pure tone, and compares the results to similar data following a 48-h exposure to the same sound. Use of Postoperative Peak Arterial Lactate Level to Predict Outcome After Cardiac Surgery. The background of ischemia/reperfusion injury is discussed as it applies to each of these 3 organs, as well as findings that ischemia followed by reperfusion results in a similar injury in each organ.

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The roles of putative neurotransmitters and neuromodulators in annelids and related invertebrates. A double-contrast MRI protocol has high accuracy in staging of HCC in patients with cirrhosis. Some mutants showed preference for N-demethylation and N-oxidation, whereas others showed high selectivity for bioactivation to reactive intermediates. One year later, the patient remains without symptoms in spite of the presence of lung metastases and the therapeutic abstention. Then, we suggest a user preference model, which can eliminate the predictions that are considered to be impracticable.

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Patients with cognitive impairment showed lower rCBF in the left frontal and temporal cortices as well as in the bilateral medial frontal and anterior cingulate cortices. Toxicologic pathologists contribute significantly to the development of new biopharmaceuticals, yet there is often a lack of awareness of this specialized role.

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Verapamil and beta-adrenoceptor blockade in the treatment of stable angina pectoris. There is a need for a patient-reported outcome (PRO) questionnaire to evaluate patients with proximal hamstring tendinopathy (PHT). Women with the ER-alpha IVS1-401 C/C genotype have greater reductions in E-selectin but no further increases in CRP with HRT. Five modifiers that act on the dominance relationships of at least one of the five possible heterozygotes of a dominant peak and its wild-type allele have been characterized, four of them having been obtained by selection directed against a phenocopy of these mutants induced by treatment of wild type with l-sorbose.

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Occupational and socio-economic risk factors for giant cell arteritis: a nationwide study based on hospitalizations in Sweden. In this article we discuss how incentive motivations and task demands affect performance. Within the limitations of this study, connective tissue graft proposed significantly more improvement as compare to connective tissue graft in pouch. Fibulin-1 (95 kDa) was readily cleaved by leucocyte elastase, weakly by matrilysin and not by the other proteases.

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The initial procedure was repeated if baseline functioning did not return 15 minutes after the initial reduction attempt. Salts of these trace elements were administered intraperitoneally daily during thirty days. Orlistat-associated adverse effects and drug interactions: a critical review.

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PMFC of PLWH was significantly lower compared to healthy controls without gender bias. Substrate-Independent, Transparent Oil-Repellent Coatings with Self-Healing and Persistent Easy-Sliding Oil Repellency. Effects of phoxim on nutrient metabolism and insulin signaling pathway in silkworm midgut. Hepatic disorders appeared earlier in the small-litter/high-fat rats with greater liver mass gain and higher hepatic triglycerides and steatosis score versus normal-litter/high-fat rats. Making the connections: Autophagy and post-translational modifications in cardiomyocytes.

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Correlation of in-vitro activity and pharmacokinetic parameters with in-vivo effect of amoxycillin, co-amoxiclav and cefotaxime in a murine model of pneumococcal pneumonia. Fructose intake has increased steadily during the past two decades.

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CREB-binding protein (CBP) and the closely related adenovirus E1A-associated 300-kD protein (p300) function as coactivators of transcription factors such as CREB, c-Fos, c-Jun, c-Myb, and several nuclear receptors. Depending upon the environmental conditions, different types of bacteria, fungi, and enzymes are involved in the degradation process of these compounds.

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The author reviews the literature regarding factors that potentially impact entry-level BSN student retention after CC transfer. Decalcification of the enamel surface adjacent to fixed orthodontic appliances, in the form of white spot lesions, is a common and frequent well-known side-effect of orthodontic treatment. Distribution characteristics and chemical pattern of cadmium in grasses planted in the cadmium contaminated soil A pragmatic means of conceptualising interventions targeted at non-conscious processes is a necessary prelude to testing the potency of such interventions. The use of exchange chromatography combined with automatic amino acid analyzer for the determination of amino acid content of red blood cell hemolysates

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Efficacy of a long-term antibacterial therapy in patients with chronic destructive pulmonary tuberculosis at a rural antituberculous dispensary Isolation and characterization of a primary proximal tubular epithelial cell model from human kidney by CD10/CD13 double labeling. Our results showed that urea application significantly increased the net nitrification rates, but were significantly inhibited by both NIs, and the inhibitory effect of DMPP was significantly greater than that of DCD.

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Mycobacterium tuberculosis genotyping can effectively improve tuberculosis (TB) control programs by controlling disease transmission. Lava cave microbial communities within mats and secondary mineral deposits: implications for life detection on other planets. Four trials met our inclusion criteria, including 662 patients randomized to prone ventilation and 609 patients to supine ventilation. The lesions are those associated with a reduction in performance traits or are indicators of animal welfare problems.

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Only five laboratories correctly identified the presence or absence of mycobacterial DNA in all 20 samples. When learning a second language does not mean losing the first: bilingual language development in low-income, Spanish-speaking children attending bilingual preschool.

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Implantable cardioverter defibrillators: physical and psychosocial outcomes. In vivo 5-HT(6) receptor occupancy by antipsychotic drugs in the rat brain. Thus a novel classification method for halftone image via statistics matrices is proposed. Effects of selective and non-selective phosphodiesterase inhibitors on tracheal mucus secretion in the rat. Polyphosphate binds to the principal sigma factor levofloxacin 500 mg knee pain of RNA polymerase during starvation response in Helicobacter pylori.

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The effect of oral irrigation with a magnetic water treatment device on plaque and calculus. The study was performed using tissue material and clinical data from 100 moxin medication side women diagnosed with VIN and 100 women diagnosed with invasive vulvar cancer. Peptide mapping allowed localization of the binding site on the 23-kDa N-terminal intracellular peptide of band 3. Incremental value of hormonal therapy for deep vein thrombosis prediction: an adjusted Wells score for women.

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For this purpose samples of peripheral blood mononuclear cells were obtained from 22 MS patients, a corresponding number of age and sex-matched healthy donors and five patients with other diseases affecting the central pantecta 40 mg dosage nervous system. Neural activation associated with semantic priming (Unrelated-Related conditions) revealed a bilateral fronto-temporo-parietal network. Segmental Renal Ischemia following Transplantation of Horseshoe Kidney as Separate Allografts. We postulate that the distinct clinical syndromes observed after bicuculline injections into the rostral and caudal motor thalamus are due to differences both in the neuronal circuitry within each thalamic nucleus and in segregated cortical projections. The P422L and S466L mutants demonstrated a level of CBS activity comparable to that of the AdoMet stimulated wild-type CBS but could not be further induced by the addition of AdoMet.

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The retinoblastoma gene product (Rb) is a nuclear phosphoprotein that regulates clindamycin mechanism of action malaria medicine cell cycle progression. Unstable syndesmosis injuries are uniformly reduced and stabilized by numerous methods.

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Transforming growth factor-alpha (TGF-alpha), present in human milk, is thought to play a significant role in postnatal gut dumozol 250 mg development. A new computational infrastructure-RNA Comparative Analysis Database (rCAD)-that utilizes a relational database was developed to manipulate and analyze very large sequence alignments and secondary-structure data sets. Reliability, validity, and precision of a handheld myometer for assessing in vivo muscle stiffness. Child Health Partnerships: a review of program characteristics, outcomes and their relationship.

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Use of triclabendazole for treatment of patients co-infected by Fasciola spp. The bell-shaped reversal curve may be related to the existence of two mu-opioid receptor subtypes, one mediating the agonist effects of opioids at low dose, the other mediating antagonistic effects at high dose. A vaginal wash technique coupled with newer molecular amplification technology may be useful in the assessment of sexually abused children. Readings with the focalin and alcohol interaction with levofloxacin OBF pneumotonometer showed a mean increase in IOP with increasing CCT of 0.28 mm Hg/10 microm, an increase of 0.23 mm Hg/10 microm with the Goldmann tonometer, and of 0.10 mm Hg/10 microm with the Tono-Pen. SRIF-like and met-enkephalin-like neurosecretory products are synthesized and carried to their release areas whilst the formation of brain structures and of the corpora cardiaca has not yet been completed.

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Transgingival probing (trans-sulcular) was done for these same patients and length of the DGU was measured. Attention is paid to surgical procedures and the expected postoperative appearance as well to commonly identified recurrent and residual disorders and surgical complications. In each section, we use recent observational studies and randomized controlled trials to illustrate trevilor 75 mg beipackzettel ismn our perspective while also providing relevant statistical comments.

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