on all orders above $300.00

FREE Pills!


for free with every order



Less than in your
local pharmacy

Search by letter:


Enter coupon: (if you have one)

Veldona (Ribavirin)

Veldona is used in combination with other antiviral medications (such as interferon, sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. Veldona works by reducing the amount of hepatitis C virus in your body, which may help your liver recover. It is not known if this treatment can prevent you from passing the virus to others. Do not share needles, and practice "safer sex" (including the use of latex condoms) to lower the risk of passing the virus to others.

Other names for this medication:
Ribavirin, Rebetol, Copegus, Alfater, Beclabuvir, Boceprevir, Daclatasvir, Daklinza, Dasabuvir, Elbasvir, Filibuvir, Hepcinat, Hepcvir, Incivek, Kipferon, Ledifos, Ledipasvir, Miravirsen, Multiferon, Olysio, Ombitasvir, Paritaprevir, Pegasys, Pegetron, Pegintron, Rebetron, Resof, Setrobuvir, Simeprevir, Sofab, Sofovir, Sovaldi, Sylatron, Technivie, Telaprevir, Veldona, Victrelis, Viroclear, Zepatier,

Similar Products:
Genoxal, Cizole, Quetiazic, Ethambutol, Veega, Eslorex, Norax, Dutagen, Flagyl, Quinobiot, Aldazida, Gabantin, Trichazole, Flox, Metrol, Makrodex, Levoxacin, Zolax, Mycoderm, Norsol, Clovate, Oxcarbazepin, Fuben, Elopram, Moxypen, Dineurin, Acnestop, Cefirax, Clomipramine, Noflo, Micosin, Warafin, Zollocid, Limpidex, Daklinza, Abilify, Perdamel, Dapoxetina, Actinex, Amobiotic, Pravil,

veldona copd treatment

The most severe affection of urodynamics (low amplitude of the peristalsis, high tonicity of UUT wall) occurred in group 4. Anthrax is a zoonotic disease caused by Bacillus anthracis, a Gram-positive spore-forming bacterium. Child and adolescent injury control: what to do when the conference is over.

veldona copd treatment

CONTROL (Cordis Corporation, Miami Lakes, Florida), second-generation and first-generation nitinol stents, in femoropopliteal lesions. The initial distribution volume of glucose (IDVG) could be a clinically useful indicator of the central extracellular fluid (ECF) space volume, namely the interstitial fluid volume status of highly perfused organs. Stiffness of large arteries has been related to cardiovascular mortality. A combinatorial approach was developed for the synthesis and the screening of a large variety of conjugated polymers.

veldona copd symptoms

It is concluded that, besides the maintenance of adequate hemodynamics, a continuous infusion of nifedipine during CPB can be an additional therapeutic tool to protect renal function in cardiac surgical patients. Neuronal cells that overexpress Beclin 1 may exhibit damaged DNA but without changes in nuclear morphology, which indicates that not all the Beclin 1-upregulating cells are predestined to die. There were 6 hips with Crowe type III and 19 hips with Crowe type IV. The putative role of resveratrol, a polyphenol present in grapes and other plants, in modulating dislypidemia, thus preventing cardiovascular diseases, is generally based on proliferating cell lines and in vivo studies in different pathological conditions. The proposed index provides an alternative complex network metric.

veldona copd medications

This report will review our experience with video assisted thoracic surgery at a level I trauma center and attempt to further delineate the indications for and timing of thoracoscopy in thoracic trauma. To present clinical data that supports and identifies the pathway of CXCR3 and its ligands in T-lymphocytic cell recruitment in vitiligo.

veldona copd symptoms

A Primary Role for Nucleus Accumbens and Related Limbic Network in Vocal Tics. The Western Ontario Rotator Cuff Index (WORC) is a self-report, disease-specific, quality-of-life assessment tool.

veldona copd symptoms

Measurements were also made of the numbers of spermatozoa ejaculated on a daily basis between 22 and 24 weeks of age, and these data were then compared with data on the hormone levels in plasma. Applying The Semistandardized Regression Coefficient To Factor, Canonical, And Path Analysis. Intermembrane electron transfer in mitochondrial and microsomal systems. Association of plasma leptin levels and insulin resistance in diabetic women: a cross-sectional analysis in an Iranian population with different results in men and women.

veldona copd medications

Our preliminary studies indicated that the linear pentaheterocyclic compound can specifically sense anions such as H2 PO4- and CN- ions, which was corroborated by absorption and fluorescence studies. After the initial observation that human and animal mononuclear phagocytes can be activated into specific killer cells against larvae of the parasite Schistosoma mansoni by seric IgE antibody from infected patients, a possible interaction of IgE with human alveolar macrophages in asthmatic patients was investigated.

veldona copd symptoms

Potential prognostic factors were analysed according to overall survival (OS), disease-free survival (DFS) and disease-specific survival (DSS). Menopause stage, HT use status, and helpfulness influenced use of physician for information.

veldona copd medications

Plasma ACTH, cortisol and aldosterone concentrations were measured before and during the 3 h following the administration of the drug. The individual trifocal tensors are then obtained from the second order derivatives of the multibody trilinear constraint. A case is reported of an intracranial neoplasm of mixed mesenchymal and neuroepithelial (glial) origin occurring in the parieto-parasagittal region of the brain of a 19 year old man. In this report, recombinant interleukin-8 (rIL-8) was produced and its activity tested for the first time in fish. Einstein-Podolsky-Rosen (EPR) steering is a type of quantum correlation which allows one to remotely prepare, or steer, the state of a distant quantum system.

veldona copd treatment

Development of genomic markers that predict response to molecularly targeted antileukemic therapy. The low pretest risk of invasive aspergillosis in the context of effective antimold prophylaxis renders serum GM surveillance of asymptomatic patients unreliable, as all results would be either negative or false positive. The second employed a mathematical ratio which combined the amplitude of evoked response and the stimulation current thresholds and confirmed the prediction of the facial function in 91.3 per cent of the patients.

veldona copd symptoms

This behavior is most likely a consequence of using constitutive extracellular ligands expressed along the pathways of preferred dissemination. By combining particle-tracking microrheology and traction force cytometry, we can monitor the mechanical properties of the actin meshwork and determine how changes in the intracellular network contribute to force generation.

veldona copd medications

Signs of sensory deprivation versus cerebral injury in post-hip-fracture patients. It is assumed that early stage Alzheimer disease patient deficits in Clock Tests are mainly determined by a reduced access to semantic memory about the appearance and functionality of a clock. Practical human abdominal fat imaging utilizing electrical impedance tomography. Histological, histochemical and experimental studies clearly indicate that the preputial gland of the rat is innervated by cholinergic as well as adrenergic nerves.

veldona copd medications

Blood pressure reduction after bradykinin infusion was more pronounced in animals treated with SERMs. The study is based on information received from a computerized data base. Fluorescein, a commonly used fluorescent probe, is metabolized within liver cells to fluorescein mono-glucuronide, which is also fluorescent. Additionally, studies have reported the possible association between H. The aim of the study was to prospectively evaluate the results of outpatient treatment of upper tract urinary stones by rigid or flexible ureteroscopy in a routine care setting.

faldaprevir deleobuvir and ribavirin dosage

  • ribavirin mechanism of action ppt to pdf
  • ribavirin dosage in lassa fever symptoms
  • ribavirin dosage with sovaldi prescribing
  • vieira pak and ribavirin side effects
  • ribavirin dose in cchfreedom
  • ribavirin interferon side effects
  • veldona copd treatment
  • ribavirin medication guide
  • copegus ribavirin tablets medication
  • faldaprevir deleobuvir and ribavirin dosage
  • ribavirin capsules storage
  • incivek ribavirin and interferon manufacturer
  • solvaldi and ribavirin treatment
  • veldona copd medications
  • ribavirin dosing schedule
  • abt-450/r abt-267 abt-333 and ribavirin package
  • ribavirin dose times of india
  • parainfluenza treatment ribavirin rash
  • ribavirin capsules vs tablets
  • hepatitis c treatment ribavirin brand
  • ribavirin dose for genotype 3 clinical trials
  • hantavirus treatment ribavirin dose
  • ribavirin drug label examples
  • ribavirin dose reduction of metformin
  • ribavirin prescription information library
  • inhaled ribavirin pregnancy exposure
  • peg interferon alfa and ribavirin dosage
  • ribavirin dose adjustment anemia in cats
  • ribavirin prescription information websites
  • interferon ribavirin telaprevir rash
  • ribavirin administration route sc
  • pegasys ribavirin dosage form
  • ribavirin dose reduction svremote
  • hplc ribavirin dosage
  • pegasys ribavirin telaprevir fda
  • sovaldi and ribavirin cure rate
  • gs 7977 plus ribavirin treatment
  • ribavirin dose in cchf africa
  • ribavirin injection spc
  • ribavirin doses
  • ribavirin injection price india
  • ribavirin side effects rsvp
  • ribavirin dosage in lassa fever virus
  • ribavirin contraindications for ultrasound
  • ribavirin tablets price in pakistan samsung
  • ribavirin dose timeshares
  • pegylated interferon alfa and ribavirin rash
  • ribavirin dosage calculation
  • ribavirin iv package insert
  • ribavirin side effects pdf printer
  • sovaldi and ribavirin reviews for horrible bosses
  • ribavirin side effects pregnancy symptoms
  • ribapak versus ribavirin and sovaldi
  • ribavirin pregnancy registry guidance
  • ribavirin side effects vision appraisal
  • ribavirin rash management recruiters
  • ribavirin dose adjustment renal impairment symptoms
  • ribavirin drug manufacturers
  • ribavirin drug manufacturer
  • ribavirin contraindications definition
  • new treatment for hep c without interferon and ribavirin
  • sofosbuvir and daclatasvir and ribavirin treatment
  • interferon ribavirin in pregnancy
  • parainfluenza treatment ribavirin for rsv
  • hepatitis c treatment interferon and ribavirin cost
  • veldona copd symptoms
  • ribavirin 200mg tab
  • ribavirin dose reduction in radiography
  • ribavirin drug label 125mg/5ml
  • ribavirin missed dose
  • ribavirin dose hepatitis c
  • ribavirin dose renal
  • ribavirin mechanism of action ppt presentation
  • ribasphere ribavirin dose
  • ribavirin dose reduction anemia during pregnancy
  • hepatitis c treatment ribavirin rsv
  • hcv ribavirin doses
  • ribavirin drug monograph

veldona copd medications

Mucocutaneous surfaces are constantly exposed to an array of exogenous antigens including environmental proteins, peptides and low molecular weight and microbial pathogens. Given our current understanding of gene expression, and the goals of biotechnology research, both scientists and engineers would benefit from detailed simulators that can explicitly compute genome-wide expression levels as a function of individual molecular events, including the activities and interactions of molecules on DNA at single base pair resolution. were among the first to standardize the definition of frailty as a distinct syndrome with biologic underpinnings. Whereas VEGF mRNA in the retina remained constant, VEGF expression was increased as early as 2 weeks after the onset of diabetes.

veldona copd medications

A qualitative analysis of the composition of the plaque can predict its potential evolutivity (chronic with slow progression or at risk of rupture and causing acute thrombosis) and its response to different types of angioplasty, which could eventually become and essential factor in the choice of appropriate therapeutic strategy. Structure ditermination of the squalene, dihydrosqualene and tetrahydrosqualene in Halobacterium cutirubrum. Assessment of TFBUT provided a reasonable clinical estimate of GCD. However, the mechanisms underlying its degradation remain poorly understood.

veldona copd treatment

Preoperative chemoradiotherapy for esophageal cancer: impressive downstaging with acceptable toxicity. Further studies reveal that the serum abundance of a polyglutamylase, tubulin tyrosine ligase-like protein 12, may show parallel with the degree of development of prostate cancer and the discrimination between early cancerous development and benign conditions. At a 2-year follow-up, the patient was pain-free and ambulating in an ankle-foot orthosis.

veldona copd treatment

The PEX4 translation product, Pex4p, is a member of the ubiquitin-conjugating enzyme family. Immunohistochemistry was used to identify cell types (monocytes/macrophages (M phi) by EBM11 and HAM56, smooth muscle cells by alpha actin). We applied a customized ASCOT model developed from our database as a tool to criticize the quality of care in a local hospital. Three metabolites (M1-M3) were quantified by HPLC, revealing a lower amount of M2 and M3 in TR(-)-rats.

veldona copd treatment

These data suggest an impact of BCECTS on attentional processes, the most affected being attention control processes that develop late. Finally, quantum chemical calculations and molecular docking studies have been performed to confirm the mode of binding of DCVJ with DNA.

veldona copd medications

These tools and the detailed results can be also used for developing new geometric distortion correction algorithms or improving the existing ones. The authors discuss methods and devices for determination of the compressive properties of elastic products in prophylaxis and treatment of the disease of lower extremity veins. Enhancement of artificial juxtacrine stimulation of insulin by co-immobilization with adhesion factors.

veldona copd symptoms

Developmental aims of clinical immunology--a weighty new gift for next year Post-traumatic stress disorder and functioning and quality of life outcomes in female Vietnam veterans. Treatment of localized tumors by focused ultrasound (FUS) is a minimally invasive therapy that uses a range of input energy for in situ tumor ablation through the generation of thermal and cavitation effect.

ribavirin side effects vision appraisal

Helicobacter pylori associated gastric intestinal metaplasia: Treatment and surveillance. Knowledge and risk perception of oral cavity and oropharyngeal cancer among non-medical university students. Elevated MCT4 expression was associated with human CRPC and an earlier time to relapse. Neuronal currents were recorded within 1 hr to assure that the characteristics of the currents resulted from developmental events occurring in vivo prior to the experiment. We performed validation of 49 AD cases and 55 controls using NGS and also included 20 mild cognitive impairment and 90 multiple sclerosis samples to identify nonspecific markers.

ribavirin pregnancy registry guidance

The psychometric model proposed in this study for assessing perceived stress is plausible based on factor analysis and will be useful for characterizing the impact of the clinical environment on subject stress levels in future investigations. Experimental EEG was fitted with parameterized spectra spanning the alpha range, with results categorized by multi-site criteria into three distinct classes: no distinguishable alpha peak, a single alpha peak, and two alpha peaks.

ribavirin injection price india

The strategy used was right radial retrograde approach with contralateral injections from left radial catheter. Clinical examination, phonocardiography and echocardiography were performed on 49 elderly patients with systolic murmurs. Here we determine the widths of metaphase spindles of various sizes observed during embryogenesis in Caenorhabditis elegans, including small spindles obtained by knocking down the tpxl-1 or spd-2 gene. dendrobatidis subtilisin-like serine protease suggests the importance of this enzyme in B.

ribavirin dosing schedule

These findings are of relevance for decisions on the efficient allocation of health care resources. Given the role of the QALYs in economic evaluation, the implications of an alternative, which generates very different results, warrant further exploration.

veldona copd treatment

Topological and regulatory aspects of dolichyl phosphate mediated glycosylation of proteins. To determine the societal costs of scleroderma (SSc), a rare chronic connective tissue disease that affects approximately 98,000 Americans. Complete genomic sequence and comparative analysis of four genital and respiratory isolates of bovine herpesvirus subtype 1.2b (BoHV-1.2b), including the prototype virus strain K22.

hplc ribavirin dosage

The identified themes are: types, causes and consequences of burdens, work as pleasure and positive attitude toward self, priorities, planning and help, and understanding of superiors, disburdening and changing in specialisation. Inclusive trauma systems must embody appropriate triage guidelines. An in vitro system for studying murid herpesvirus-4 latency and reactivation. Eighteen experienced footballers took five penalty kicks under counterbalanced conditions of threat (low vs. An increase in plasma triglyceride levels in women with low levels of endogenous estrogen appeared to cause the size of LDL particles to be reduced.

ribavirin 200mg tab

The data also indicate that ionization/photoelectric sensors can be utilized to measure continuously and in real time aerosol properties over a broad spectrum of applications related to adverse environmental and health effects. Axial spiral CT may simplify preoperative evaluation of periampullary tumors. The Frontal Systems Behaviour Scale (FrSBe) as a predictor of community integration following a traumatic brain injury. The results obtained on regional roads showed that heavy-duty vehicles in traffic seem to have a major impact on on-road air quality. Multiple-dose pharmacokinetics of pentoxifylline and its metabolites during renal insufficiency.

ribavirin dose adjustment renal impairment symptoms

Our study also revealed that female patients who acquired ambulatory ability were likely to be at risk for obesity. It covered an area of 0.087 micron2, contained 530 particles and had a particle-packing density of 6078 particles/micron2. ArduiPod Box: a low-cost and open-source Skinner box using an iPod Touch and an Arduino microcontroller. Substrate-bound carbohydrates stimulate signal transduction and neurite outgrowth in an olfactory neuron cell line. A system for production of commercial quantities of human lactoferrin: a broad spectrum natural antibiotic.

ribavirin drug label examples

The major conclusion is that among those quantities recommended, the NCCLS algorithms present the most sensible overall approach and that we would recommend their use as described so that the quantities can be most effectively applied clinically, without differences in final values occurring due solely simple algorithm differences. In the first place, they offer a means of sustained release of the various ingredients. We propose a model in which the cAMP-signalling pathway has a role in the maintenance of gene expression, rather than in the determination of a specific programme.

ribavirin drug label examples

Neocortical absence of HuR alters the phosphorylation states of initiation and elongation factors in the core translation machinery. Criteria-specific long-term survival prediction model for hepatocellular carcinoma patients after liver transplantation.

ribavirin missed dose

Helicobacter pylori ATCC 43629/NCTC 11639 Outer Membrane Vesicles (OMVs) from Biofilm and Planktonic Phase Associated with Extracellular DNA (eDNA). coli transformed with a plasmid encoding the kanamycin phosphotransferase gene has been studied. restrictus genome revealed a rather elaborate genome with predicted pathways that were not suspected from its restricted metabolism, such as a complete corrinoid biosynthetic pathway, the Wood-Ljungdahl (WL) pathway for CO2 fixation, abundant transcriptional regulators and several types of hydrogenases. Primary olfactory axons of single and double mutants exited the olfactory epithelium and projected toward the telencephalon, but displayed differences in fasciculation. MRI findings were graded according to the system described by Pfirrmann et al.

ribavirin administration route sc

Moreover, by using low frequency components, the proposed features are very robust to noise. While it is obvious that excessive and imprudent use of antibiotics significantly contributes to the emergence of resistant strains, antibiotic resistance is also observed in natural bacteria of remote places unlikely to be impacted by human intervention.

parainfluenza treatment ribavirin rash

In this way, we proposed a multi-phase cost function to describe the STS task. In two patients with extensive marrow necrosis, the diagnosis of marrow necrosis was established by morphologic and radioisotopic studies, and the extent of involvement was accurately assessed by marrow scanning with technetium Tc 99m sulfur colloid while the patients were still alive.

ribavirin drug monograph

Clinical experience with non-penetrating vascular clips in free-flap reconstructions. Infants thinner at birth exhibit smaller kidneys for their size in late gestation in a sample of fetuses with appropriate growth. These precautions include limiting packing, crushing, and manipulating of tissues to what is strictly required for safe completion of the procedure. SNPs shrank until neutralization, upon which they destabilized and aggregated.

ribavirin missed dose

Postural sway measures were associated with walking speed, stride length and percentage of the stride in the stance phase. A joint team from the Swiss Federal Institute of Aquatic Science and Technology (Eawag) and Leibniz Institute of Plant Biochemistry (IPB) participated in CASMI 2013 with an automatic workflow-style entry.

incivek ribavirin and interferon manufacturer

Her disease had relapsed despite appropriate medical management with mycophenolate mofetil (MMF), as evidenced by rising acute phase response and antimyeloperoxidase titre with ongoing symptoms. The authors propose twelve information cards corresponding to the most currently operations of plastic and aesthetic surgery.

ribavirin dose timeshares

Clinical, demographic, behavioural and diagnostic data were compared with gay men attending a clinic-based service during 2009. The assay was found to be technically simple, precise, sensitive and specific for DNA. Inhibition of hepatoma cell growth by analogs of adenosine and cyclic AMP and the influence of enzymes in mammalian sera. Consequently, CpG-DNA activated microglial cells in vitro and induced TNF-alpha, IL-12p40, IL-12p70, and NO. A dedicated Vascular Surgical Unit in a University teaching hospital.

 Show Hide 
ribavirin drug manufacturer 2016-04-13

The toxic effects of dissolved versus bioconcentrated tributyl tin (TBT) on oyster larvae were compared. omeprazole and plavix contraindications The data did not support the construct validity of DSM-IV alcohol abuse when applied to adolescents, and suggested staging among DSM-IV alcohol dependence symptoms. Significant correlations were noted between MIB-1 LI and pRb LI, MIB-1 LI and cycD1 LI, MIB-1 LI and p27 LI (inverse), pRb LI and cycD1 LI, cycD1 LI and cdk4 LI and pRb LI and p27 LI (inverse) in the pRb/cycD1-cdk4/p27 pathway, and between MIB-1 LI and p53 LI, MIB-1 LI and p14 LI, p53 LI and p14 LI, p53 LI and MDM2 LI and MDM2 LI and p14 LI in the p53/MDM2/p14 pathway. Limited CYP2D6 activities because of a genetic defect or co-medications with CYP2D6 substrates should therefore not give rise to elevated moclobemide blood levels.

sovaldi and ribavirin reviews for horrible bosses 2015-10-17

Although both dhc-1(or195ts) and lis-1 loss-of-function disrupt the actin cytoskeleton and produce embryonic lethality, a double mutant suppresses these defects. We aimed to apply this knowledge to the development of the functionality of an app targeting weight loss maintenance. An autoradiographic study of serotonergic receptors in amoxidin 500 mg a murine genetic model of anxiety-related behaviors. However, no pharmaceutical agent in 20 years has extended lifespan by more than a few weeks.

solvaldi and ribavirin treatment 2011-07-25

This study aims to analyse data on spontaneous reports to the French System of Pharmacovigilance of adverse reactions to quinine drug products. This treatment regimen was shown to significantly increase the extracellular pH, but not the intracellular pH, of tumors by (31)P magnetic resonance spectroscopy and the export of acid from growing tumors by fluorescence microscopy of tumors grown in window chambers. The nonideal clovate crema psoriasis treatment conditions under which doctors and nurses work in developing nations mandate resource allocation to be an integral component of NICU care.

ribavirin dose in cchf africa 2016-05-29

Internal-external control and attribution of responsibility for success and failure. Projections indicate that the trend in longevity improvements in favor of males will continue. For fish immune defences, cytokines and anti-microbial peptides (lysozyme) in circulating system play important roles. Ketanserin and justaucorps danse classique vicard medicine erythropoiesis in hemodialysis patients with polycystic kidneys. The turnaround time of the IOC was calculated from the arrival of the specimen at the pathology laboratory until the time of the call to the surgeon.

ribavirin dose reduction anemia during pregnancy 2012-09-27

The endocrine disruptor nonylphenol preferentially blocks cyclooxygenase-1. M4, that was reversed by transferring the cells to beclabuvir fda approval a fresh control medium. An 85-year-old man with chronic alcoholism presented several symmetrical lipomas of the tongue with no other clinical manifestations.

hepatitis c treatment ribavirin rsv 2012-01-27

Metered-dose inhaler technique and quality of life with airways disease: assessing the value of the Vitalograph in educational intervention. There are excitatory and inhibitory mechanisms that control these behaviors whose mediators and interactions are unclear. It was determined that in such men selection for necropsy was similar in coalworkers and non-coalworkers. A case of local gigantism of the thumb was studied by light and electron microscopy. Mounting evidence pantorc 20 mg prezzo offers suggests that glutamate receptor-mediated synaptic plasticity, in particular long-term depression (LTD), is important for elimination of synaptic contacts in brain development.

pegasys ribavirin dosage form 2011-02-15

Considering the extremely poor survival, supportive care alone may be considered if pain relief is achieved without irradiation. In contrast, contact noprose tablets en walmart between B19 and inappropriate muscle targets failed to induce changes in presynaptic secretory properties. In mice, N-acetyltransferase and N,O-acetyltransferase seem not to exhibit this relationship.

ribavirin capsules vs tablets 2019-09-17

There were no clinically relevant negative outcomes postimmunizations. In the absence of osteogenic supplements, MC3T3-E1 metabolic activity and alkaline dosage clavamox for cats phosphatase production were affected by the presence of nBG, indicating accelerated osteogenic differentiation.

ribavirin rash management recruiters 2014-05-08

This study was designed nizole medication to investigate whether E(2) can directly regulate NPY secretion and examine the cellular mechanisms and receptors responsible for this anorexigenic action of E(2). In this review we provide some examples, and discuss how X-ray crystallography and cryo-EM can be combined in deciphering structures of macromolecules for our full understanding of their biological mechanisms.